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Table 2 Ranking of the top 10 upregulated and downregulated differentially expressed genes in the CpG DNA dataset. Ranking based on fold change

From: Bacterial and viral pathogen-associated molecular patterns induce divergent early transcriptomic landscapes in a bovine macrophage cell line

Gene

ID

Name

Fold change

p value

FDR

A

TNFSF18

768,081

tumor necrosis factor superfamily member 18

5.3

6.9 × 10−4

2.4 × 10− 2

Slc26a10

506,076

solute carrier family 26 member 10

4.3

1.2 × 10−3

3.5 × 10− 2

NR4A1

528,390

nuclear receptor subfamily 4 group A member 1, transcript variant X3

3.1

9.7 × 10−5

6.2 × 10− 3

IGFLR1

617,594

IGF like family receptor 1

3.1

6.6 × 10−5

4.7 × 10−3

GSDMB

509,296

gasdermin B

2.5

6.4 × 10−5

4.6 × 10−3

LBH

616,148

limb bud and heart development

2.2

6.7 × 10−14

4.6 × 10− 10

LY6G5B

539,236

lymphocyte antigen 6 complex, locus G5B

2.2

1.4 × 10−3

3.9 × 10− 2

MYOZ2

540,487

myozenin 2, transcript variant X1

2.7

4.01 × 10−5

3.5 × 10−3

RRAD

505,165

Ras-related associated with diabetes

2.0

5.8 × 10−5

4.3 × 10−3

PLAU

281,983

plasminogen activator, urokinase receptor

1.7

4.6 × 10−8

2.1 × 10−5

B

CYP1A1

282,870

cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1, transcript variant X2

−2.8

4.3 × 10−10

6.6 × 10−7

CYP1B1

511,470

cytochrome P450, family 1, subfamily B, polypeptide 1

−2.4

2.0 × 10− 10

4.0 × 10−7

ID1

497,011

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

−2.4

3.5 × 10− 16

4.9 × 10− 12

GPR35

505,056

G protein-coupled receptor 35, transcript variant X7

− 2.4

2.4 × 10−4

1.2 × 10− 2

SLC25A34

515,553

solute carrier family 25 member 34

− 2.3

2.3 × 10−5

2.4 × 10− 3

EDN2

319,094

endothelin 2, transcript variant X1

− 2.1

3.4 × 10−8

1.7 × 10−5

ATOH8

616,225

atonal bHLH transcription factor 8, transcript variant X1

−2.1

5.1 × 10− 9

4.4 × 10− 6

ID3

538,690

inhibitor of DNA binding 3, dominant negative helix-loop-helix protein

−2.0

1.2 × 10− 12

5.8 × 10− 9

BDKRB1

532,119

bradykinin receptor B1

−1.9

1.1 × 10−4

6.7 × 10− 3

  1. (A) upregulated, (B) downregulated. Data were analyzed in IPA (QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis