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Table 4 Kyoto Encyclopedia of Genes and Genomes pathways generated from CpG DNA or poly(I:C)-stimulated Bomac cells tested at 6 h post stimulation vs control cells

From: Bacterial and viral pathogen-associated molecular patterns induce divergent early transcriptomic landscapes in a bovine macrophage cell line

A KEGG ID Pathway Na b p-value c p-value
a path:bta04974 Protein digestion and absorption 42 15 1.2 × 10− 20 0 1
path:bta04512 ECM-receptor interaction 55 15 5.5 × 10−18 0 1
path:bta04151 PI3K-Akt signaling pathway 233 22 1.3 × 10−16 4 4.3 × 10−2
path:bta04510 Focal adhesion 162 14 5.5 × 10−10 4 1.8 × 10−2
path:bta04360 Axon guidance 141 12 3.2 × 10−09 4 7.4 × 10−3
b path:bta04151 PI3K-Akt signaling pathway 233 22 1.3 × 10−16 4 4.3 × 10−2
path:bta04514 Cell adhesion molecules (CAMs) 65 7 7.2 × 10−07 1 2.7 × 10−1
path:bta04210 Apoptosis 121 9 1.4 × 10−06 3 3.2 × 10−2
path:bta03320 PPAR signaling pathway 44 6 1.7 × 10−06 1 2.1 × 10−1
path:bta04060 Cytokine-cytokine receptor interaction 101 6 5.6 × 10−05 3 8.7 × 10−3
B
a path:bta04621 NOD-like receptor signaling pathway 119 39 3.9 × 10−38 2 2.4 × 10−1
path:bta05168 Herpes simplex infection 146 42 4.9 × 10−38 1 6.9 × 10−1
path:bta05164 Influenza A 127 35 6.0 × 10−31 2 2.8 × 10−1
path:bta05162 Measles 91 26 2.8 × 10−23 2 1.8 × 10−1
path:bta04622 RIG-I-like receptor signaling pathway 48 19 1.6 × 10−20 0 1
b path:bta04621 NOD-like receptor signaling pathway 119 39 3.9 × 10−38 2 2.4 × 10−1
path:bta04622 RIG-I-like receptor signaling pathway 48 19 1.6 × 10−20 0 1
path:bta04668 TNF signaling pathway 84 22 1.1 × 10− 19 3 2.8 × 10−2
path:bta04612 Antigen processing and presentation 48 18 2.4 × 10− 19 0 1
path:bta04064 NF-kappa B signaling pathway 62 17 5.4 × 10−16 0 1
  1. anumber of genes in the pathway; bnumber of genes up-regulated in the pathway; cnumber of genes down-regulated in the pathway
  2. (A) CpG DNA, (B) poly(I:C). (Aa and Ba) Represent top 5 pathways in CpG DNA and poly(I:C) datasets respectively; (Ab and Bb) represent top 5 pathways of immune related genes in the datasets. Gene names in each pathway are shown in the Additional file 3