Table 4 Kyoto Encyclopedia of Genes and Genomes pathways generated from CpG DNA or poly(I:C)-stimulated Bomac cells tested at 6 h post stimulation vs control cells
A | KEGG ID | Pathway | Na | ↑b | p-value | ↓c | p-value |
|---|---|---|---|---|---|---|---|
a | path:bta04974 | Protein digestion and absorption | 42 | 15 | 1.2 × 10− 20 | 0 | 1 |
path:bta04512 | ECM-receptor interaction | 55 | 15 | 5.5 × 10−18 | 0 | 1 | |
path:bta04151 | PI3K-Akt signaling pathway | 233 | 22 | 1.3 × 10−16 | 4 | 4.3 × 10−2 | |
path:bta04510 | Focal adhesion | 162 | 14 | 5.5 × 10−10 | 4 | 1.8 × 10−2 | |
path:bta04360 | Axon guidance | 141 | 12 | 3.2 × 10−09 | 4 | 7.4 × 10−3 | |
b | path:bta04151 | PI3K-Akt signaling pathway | 233 | 22 | 1.3 × 10−16 | 4 | 4.3 × 10−2 |
path:bta04514 | Cell adhesion molecules (CAMs) | 65 | 7 | 7.2 × 10−07 | 1 | 2.7 × 10−1 | |
path:bta04210 | Apoptosis | 121 | 9 | 1.4 × 10−06 | 3 | 3.2 × 10−2 | |
path:bta03320 | PPAR signaling pathway | 44 | 6 | 1.7 × 10−06 | 1 | 2.1 × 10−1 | |
path:bta04060 | Cytokine-cytokine receptor interaction | 101 | 6 | 5.6 × 10−05 | 3 | 8.7 × 10−3 | |
B | |||||||
a | path:bta04621 | NOD-like receptor signaling pathway | 119 | 39 | 3.9 × 10−38 | 2 | 2.4 × 10−1 |
path:bta05168 | Herpes simplex infection | 146 | 42 | 4.9 × 10−38 | 1 | 6.9 × 10−1 | |
path:bta05164 | Influenza A | 127 | 35 | 6.0 × 10−31 | 2 | 2.8 × 10−1 | |
path:bta05162 | Measles | 91 | 26 | 2.8 × 10−23 | 2 | 1.8 × 10−1 | |
path:bta04622 | RIG-I-like receptor signaling pathway | 48 | 19 | 1.6 × 10−20 | 0 | 1 | |
b | path:bta04621 | NOD-like receptor signaling pathway | 119 | 39 | 3.9 × 10−38 | 2 | 2.4 × 10−1 |
path:bta04622 | RIG-I-like receptor signaling pathway | 48 | 19 | 1.6 × 10−20 | 0 | 1 | |
path:bta04668 | TNF signaling pathway | 84 | 22 | 1.1 × 10− 19 | 3 | 2.8 × 10−2 | |
path:bta04612 | Antigen processing and presentation | 48 | 18 | 2.4 × 10− 19 | 0 | 1 | |
path:bta04064 | NF-kappa B signaling pathway | 62 | 17 | 5.4 × 10−16 | 0 | 1 | |