Delineation of the pan-proteome of fish-pathogenic Streptococcus agalactiae strains using a label-free shotgun approach

Tavares, Guilherme Campos; Pereira, Felipe Luiz; Barony, Gustavo Morais; Rezende, Cristiana Perdigão; da Silva, Wanderson Marques; de Souza, Gustavo Henrique Martins Ferreira; Verano-Braga, Thiago; de Carvalho Azevedo, Vasco Ariston; Leal, Carlos Augusto Gomes; Figueiredo, Henrique César Pereira

doi:10.1186/s12864-018-5423-1

Table 4 Proteins potentially involved in virulence identified in the pan-proteome of fish-adapted GBS strains

From: Delineation of the pan-proteome of fish-pathogenic Streptococcus agalactiae strains using a label-free shotgun approach

Accession	Description	H^a	F^b	Function	Reference^c
Adhesion
SaSA20_0637	Elongation factor Tu	X	X	Mediate bacterium binding to fibronectin, fibrinogen and mucin	[76,77,78]
SaSA20_0646	Cell wall surface anchor protein	X	X	Cell adhesion	[23]
SaSA20_0697	gapN Glyceraldehyde-3-phosphate dehydrogenase	X		GBS adhesion to extracellular matrix and cytoskeletal proteins of host cells	[101]
SaSA20_1009	Dihydroorotate dehydrogenase (PavA)	X		Interacts with cell surface fibronectin	[102]
SaSA20_1475	gap Glyceraldehyde-3-phosphate dehydrogenase	X	X	GBS adhesion to extracellular matrix and cytoskeletal proteins of host cells	[101]
SaSA20_1675	Hypothetical protein (BibA)	X	X	GBS adhesion to human epithelial cells and binding to complement regulatory protein C4bp, acting as anti-phagocytic factor	[74]
Evasion
GBS_RS07805	Nucleotide sugar dehydratase	X	X	Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis	[28]
SaSA16_1205	Family 2 glycosyltransferase			Acts in immune recognition, bacterial evasion, intercellular signaling and biofilm formation	[85]
SaSA20_0016	PcsB protein	X		Peptidoglycan hydrolase	[23]
SaSA20_0031	sip Group B streptococcal surface immunogenic protein	X	X	Protective antigen and vaccine target	[93]
SaSA20_0382	Reticulocyte binding protein	X		Carbohydrate binding	[23]
SaSA20_0980	neuA N-acylneuraminate cytidylyltransferase	X		Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis	[28]
SaSA20_0981	NeuD protein	X		Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis	[28]
SaSA20_0982	UDP-N-acetylglucosamine-2-epimerase NeuC	X		Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis	[28]
SaSA20_0983	N-acetyl neuramic acid synthetase NeuB	X		Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis	[28]
SaSA20_0987	Capsular polysaccharide biosynthesis protein	X		Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis	[28]
SaSA20_0990	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase	X	X	Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis	[28]
SaSA20_0992	Tyrosine-protein kinase CpsD	X	X	Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis	[28]
SaSA20_0993	Capsular polysaccharide biosynthesis protein CpsC	X		Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis	[28]
SaSA20_0994	Tyrosine-protein phosphatase CpsB	X		Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis	[28]
SaSA20_1017	rmlB dTDP-glucose 4,6-dehydratase	X		Biosynthesis of group B antigen	[28]
SaSA20_1018	rmlC dTDP-4-dehydrorhamnose 3,5-epimerase	X		Biosynthesis of group B antigen	[28]
SaSA20_1019	rmlA Glucose-1-phosphate thymidylyltransferase	X		Biosynthesis of group B antigen	[28]
SaSA20_1438	Peptidase	X	X	Prevention of complement factor C5a deposition and phagocytosis from host cells	[57]
Invasin
GBS_RS03175	TlyA family rRNA (cytidine-2’-O)-methyltransferase	X		Hemolytic activity in different pathogenic bacteria	[103]
SaSA20_0534	eno Enolase	X	X	Binding or activation of plasminogen by GBS during incubation in human blood	[29]
SaSA20_0586	Glycosyl transferase family 1 (IagA)	X	X	GBS blood-brain barrier penetration in neonates	[75]
SaSA20_1659	cAMP fator	X	X	Forms pore on membrane of the host cells	[57]
SaSA53_0799	Internalin			Required by Listeria monocytogenes for invasion of different nonphagocytic mammalian cell lines	[104]
Multidrug Resistance
SaSA20_0259	pbpX Penicillin-binding protein 2x	X		Mediate GBS resistance to AMPs	[57]
SaSA20_0270	Penicillin-binding protein 1A	X		Mediate GBS resistance to AMPs	[57]
SaSA20_1495	D-alanyl-lipoteichoic acid biosynthesis protein DltD	X	X	Resist AMPs is to decrease the charge on their cell surface	[57]
SaSA20_1499	dltA D-alanine--poly(phosphoribitol) ligase subunit 1	X	X	Resist AMPs is to decrease the charge on their cell surface	[57]
SaSA20_1677	pbp2A Penicillin-binding protein 2A	X		Mediate GBS resistance to AMPs	[57]

^aThe letter X in this column represents that the virulence protein was previously identified in GBS human strains
^bThe letter X in this column represents that the virulence protein was previously identified in GBS fish strains
^cReference based on function of each virulence protein

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ISSN: 1471-2164

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