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Table 4 Proteins potentially involved in virulence identified in the pan-proteome of fish-adapted GBS strains

From: Delineation of the pan-proteome of fish-pathogenic Streptococcus agalactiae strains using a label-free shotgun approach

Accession Description Ha Fb Function Referencec
Adhesion
 SaSA20_0637 Elongation factor Tu X X Mediate bacterium binding to fibronectin, fibrinogen and mucin [76,77,78]
 SaSA20_0646 Cell wall surface anchor protein X X Cell adhesion [23]
 SaSA20_0697 gapN Glyceraldehyde-3-phosphate dehydrogenase X   GBS adhesion to extracellular matrix and cytoskeletal proteins of host cells [101]
 SaSA20_1009 Dihydroorotate dehydrogenase (PavA) X   Interacts with cell surface fibronectin [102]
 SaSA20_1475 gap Glyceraldehyde-3-phosphate dehydrogenase X X GBS adhesion to extracellular matrix and cytoskeletal proteins of host cells [101]
 SaSA20_1675 Hypothetical protein (BibA) X X GBS adhesion to human epithelial cells and binding to complement regulatory protein C4bp, acting as anti-phagocytic factor [74]
Evasion
 GBS_RS07805 Nucleotide sugar dehydratase X X Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis [28]
 SaSA16_1205 Family 2 glycosyltransferase    Acts in immune recognition, bacterial evasion, intercellular signaling and biofilm formation [85]
 SaSA20_0016 PcsB protein X   Peptidoglycan hydrolase [23]
 SaSA20_0031 sip Group B streptococcal surface immunogenic protein X X Protective antigen and vaccine target [93]
 SaSA20_0382 Reticulocyte binding protein X   Carbohydrate binding [23]
 SaSA20_0980 neuA N-acylneuraminate cytidylyltransferase X   Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis [28]
 SaSA20_0981 NeuD protein X   Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis [28]
 SaSA20_0982 UDP-N-acetylglucosamine-2-epimerase NeuC X   Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis [28]
 SaSA20_0983 N-acetyl neuramic acid synthetase NeuB X   Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis [28]
 SaSA20_0987 Capsular polysaccharide biosynthesis protein X   Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis [28]
 SaSA20_0990 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase X X Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis [28]
 SaSA20_0992 Tyrosine-protein kinase CpsD X X Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis [28]
 SaSA20_0993 Capsular polysaccharide biosynthesis protein CpsC X   Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis [28]
 SaSA20_0994 Tyrosine-protein phosphatase CpsB X   Prevents deposition of complement factor C3b and inhibits the opsonophagocytosis [28]
 SaSA20_1017 rmlB dTDP-glucose 4,6-dehydratase X   Biosynthesis of group B antigen [28]
 SaSA20_1018 rmlC dTDP-4-dehydrorhamnose 3,5-epimerase X   Biosynthesis of group B antigen [28]
 SaSA20_1019 rmlA Glucose-1-phosphate thymidylyltransferase X   Biosynthesis of group B antigen [28]
 SaSA20_1438 Peptidase X X Prevention of complement factor C5a deposition and phagocytosis from host cells [57]
Invasin
 GBS_RS03175 TlyA family rRNA (cytidine-2’-O)-methyltransferase X   Hemolytic activity in different pathogenic bacteria [103]
 SaSA20_0534 eno Enolase X X Binding or activation of plasminogen by GBS during incubation in human blood [29]
 SaSA20_0586 Glycosyl transferase family 1 (IagA) X X GBS blood-brain barrier penetration in neonates [75]
 SaSA20_1659 cAMP fator X X Forms pore on membrane of the host cells [57]
 SaSA53_0799 Internalin    Required by Listeria monocytogenes for invasion of different nonphagocytic mammalian cell lines [104]
Multidrug Resistance
 SaSA20_0259 pbpX Penicillin-binding protein 2x X   Mediate GBS resistance to AMPs [57]
 SaSA20_0270 Penicillin-binding protein 1A X   Mediate GBS resistance to AMPs [57]
 SaSA20_1495 D-alanyl-lipoteichoic acid biosynthesis protein DltD X X Resist AMPs is to decrease the charge on their cell surface [57]
 SaSA20_1499 dltA D-alanine--poly(phosphoribitol) ligase subunit 1 X X Resist AMPs is to decrease the charge on their cell surface [57]
 SaSA20_1677 pbp2A Penicillin-binding protein 2A X   Mediate GBS resistance to AMPs [57]
  1. aThe letter X in this column represents that the virulence protein was previously identified in GBS human strains
  2. bThe letter X in this column represents that the virulence protein was previously identified in GBS fish strains
  3. cReference based on function of each virulence protein