Delineation of the pan-proteome of fish-pathogenic Streptococcus agalactiae strains using a label-free shotgun approach

Tavares, Guilherme Campos; Pereira, Felipe Luiz; Barony, Gustavo Morais; Rezende, Cristiana Perdigão; da Silva, Wanderson Marques; de Souza, Gustavo Henrique Martins Ferreira; Verano-Braga, Thiago; de Carvalho Azevedo, Vasco Ariston; Leal, Carlos Augusto Gomes; Figueiredo, Henrique César Pereira

doi:10.1186/s12864-018-5423-1

Table 5 List of differentially regulated proteins identified in all fish-adapted GBS strains compared to the NEM316 strain

From: Delineation of the pan-proteome of fish-pathogenic Streptococcus agalactiae strains using a label-free shotgun approach

Up/Down^a	Accession^b	Product^c	SA16 fold-change^d	SA20 fold-change^d	SA53 fold-change^d	SA81 fold-change^d	SA95 fold-change^d
Down	GBS_RS00535	50S ribosomal protein L6	−4.57	−3.45	− 4.69	− 4.37	− 1.78
Down	SaSA20_0140	Fe-S assembly protein NifU	−4.23	−2.33	−3.59	− 1.40	− 1.12
Down	GBS_RS01110	Acetate kinase	−2.95	−1.73	−2.03	− 1.42	− 1.15
Down	SaSA20_0551	Beta-lactamase	−5.34	−5.25	−4.93	− 5.62	−1.32
Down	SaSA20_0944	thrB Homoserine kinase	−4.67	−3.52	−2.85	− 3.46	− 4.69
Down	SaSA20_1545	Peptidase S66	−1.84	− 1.06	− 1.83	− 1.02	−1.16
Down	GBS_RS09900	Proline--tRNA ligase	−3.45	− 3.01	− 3.36	−2.68	− 2.93
Down	SaSA20_1738	DHH family phosphoesterase	−3.99	−2.65	−2.69	−1.84	− 2.15
Down	SaSA20_1009	Dihydroorotate dehydrogenase	−2.62	−2.13	−3.66	−1.22	−1.58
Down	SaSA53_1431	3-hydroxybutyryl-CoA dehydrogenase	−1.30	−2.33	−1.71	− 1.64	−1.21
Down	GBS_RS01730	Hypothetical protein	−4.30	−4.42	−3.84	− 4.19	−1.16
Up	GBS_RS07220	DNA (cytosine-5-)-methyltransferase	6.76	2.53	7.20	5.40	1.05
Up	GBS_RS07415	ABC transporter ATP-binding protein	2.06	3.34	1.40	3.30	2.38
Up	SaSA20_0474	mlcE	1.55	2.47	2.62	2.06	1.37
Up	SaSA20_0529	gyrB DNA gyrase subunit B	5.10	6.07	5.44	5.55	2.71
Up	SaSA20_1579	galE_2 UDP-glucose 4-epimerase	1.07	1.52	1.45	1.69	1.02
Up	SaSA20_0382	Reticulocyte binding protein	4.98	4.52	5.45	4.21	1.51
Up	SaSA20_0123	argH Argininosuccinate lyase	1.74	2.78	2.58	2.05	1.97
Up	SaSA95_0249	cglA Competence protein	6.16	7.67	6.80	6.31	5.25
Up	SaSA20_0173	Thioredoxin	3.14	3.43	3.52	3.71	1.03
Up	SaSA53_0400	Hypothetical protein	3.86	3.72	7.25	4.21	1.78
Up	SaSA20_0423	GNAT family acetyltransferase	3.36	5.04	5.44	5.31	1.94
Up	SaSA20_0437	asnA Aspartate--ammonia ligase	4.12	3.94	3.28	3.90	1.46
Up	SaSA20_0674	nagB Glucosamine-6-phosphate deaminase	4.61	5.11	6.03	3.37	2.54
Up	SaSA20_0995	LytR family transcriptional regulator	2.58	2.06	1.94	2.97	1.15
Up	SaSA20_1068	fni Isopentenyl-diphosphate delta-isomerase	4.28	4.82	4.21	5.04	1.77
Up	SaSA20_1080	Antibiotic ABC transporter ATP-binding protein	2.07	2.42	1.73	2.42	1.02
Up	SaSA20_1112	thiI tRNA sulfurtransferase	3.29	2.89	2.73	3.08	1.29
Up	SaSA20_1168	sigA RNA polymerase sigma factor	3.52	5.44	4.82	4.98	1.77
Up	SaSA20_1173	Amino acid ABC transporter substrate-binding protein	1.43	2.94	1.35	1.86	1.41
Up	SaSA20_1287	3-phosphoglycerate dehydrogenase	1.03	2.35	2.37	1.31	1.27
Up	SaSA20_1317	Non-canonical purine NTP pyrophosphatase	2.09	2.20	3.83	2.47	1.38
Up	SaSA53_1361	Non-canonical purine NTP pyrophosphatase	2.09	2.20	3.83	2.47	1.38
Up	SaSA20_1402	scrK Fructokinase	2.78	1.32	2.16	3.81	2.31
Up	SaSA20_1492	hypothetical protein	3.04	2.26	3.15	3.02	1.29
Up	SaSA20_1499	dltA	2.74	3.09	2.94	3.38	1.09
Up	SaSA20_1688	ABC transporter ATP-binding protein	8.13	7.87	7.46	7.26	3.66
Up	SaSA20_1692	Glyoxalase	2.32	3.16	2.77	3.06	1.43
Up	SaSA20_1762	arcB Ornithine carbamoyltransferase	2.85	2.82	2.71	3.01	1.09
Up	SaSA16_1675	Hypothetical protein	1.91	2.40	2.35	2.81	3.39

^aRegulation of protein expression
^bLocus tag of protein
^cProtein product name
^dFold-change is the log2 of ratio between fish-adapted GBS strains and NEM316 proteins abundance

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ISSN: 1471-2164

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