Fig. 4

STRING pathway analyses diagram for genes upregulated in males. Based on genes identified to be upregulated in males, two main clusters are identified with one cluster comprised of genes such as Myl1, Mb, Trdn, Myl2, Csrp3, and Smpx in the center. The second cluster includes Fmod, Omd, Ogn, Dcn, Col3a1, and Lum. Network nodes represent proteins. Splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus. Node colors are arbitrary. Edges represent protein-protein associations. Associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other. Edge confidence is the relative amount of supporting evidence for the connection between two proteins in the diagram. Thicker lines have more support; thinner lines have less support