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Fig. 1 | BMC Genomics

Fig. 1

From: Dosage sensitivity of X-linked genes in human embryonic single cells

Fig. 1

No X-chromosome dosage compensation in human single-cell RNA-seq expression profiles. (a) Ratio of the median mRNA expression between X-linked and autosomal genes at cell population level. Error bars show 90% confidence intervals of the medians, estimated by respectively bootstrapping X-linked and autosomal genes 1000 times. (b) Ratio of median mRNA expression between X-linked and autosomal genes was calculated for each single-cell. The median and range (minimum to maximum) of these ratios were indicated by the points (circles or triangles) and the error bars, respectively. In all panels, data from male and female cells are represented by triangles and circles, respectively. Two-tailed Mann–Whitney U test was used to test the equality of the mean expression ratio with 1 (filled symbols, P < 0.05; open symbols, P ≥ 0.05). E3 to E7 indicate embryonic days of the trophectoderm (TE), primitive endoderm (PE) and epiblast (EPI) lineages

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