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Table 1 TF motifs over-represented in the induced enhancers

From: Transcriptionally induced enhancers in the macrophage immune response to Mycobacterium tuberculosis infection

TF Motif

# overlapping enhancers

Expression, TPM

log2FC

FDR

FOSL1::JUNB

118 (45.9%)

19.4 / 523.7

5.4 / 2.6

2.7e-03 / 1e-04

RBPJ

117 (45.5%)

295.7

1.8

7.3e-03

REL

96 (37.4%)

165.3

3

4.3e-06

FOSL2::JUNB

91 (35.4%)

81.2 / 523.7

2.4 / 2.6

1.2e-06 / 1e-04

IRF1

88 (34.2%)

1099.8

2.8

1.5e-04

RELA

87 (33.9%)

309

1.7

1e-06

JUNB

84 (32.7%)

523.7

2.6

1e-04

FOSL1

80 (31.1%)

19.4

5.4

2.7e-03

FOSL2

80 (31.1%)

81.2

2.4

1.2e-06

Nfe2l2

54 (21%)

684

1.5

2.4e-03

JDP2

53 (20.6%)

67.7

2.9

4.8e-04

NFKB2

28 (10.9%)

496.3

2.7

2.5e-04

  1. Columns show TF motif name, number and percentage of overlapping enhancers among the induced enhancers, average expression of the corresponding TF(s) in infected BMDM at 4 h, fold change and FDR of differentially expressed test for the corresponding TF(s) in infected BMDM at 4 h versus non-infected control at 0 h. Motifs were retained for TFs with significant up-regulation at 4 h
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BMC Genomics

ISSN: 1471-2164

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