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Table 1 Overview of proteins and transcripts differentially regulated between natural population and symbionts-depleted conditions and involved in immune related pathways

From: Global host molecular perturbations upon in situ loss of bacterial endosymbionts in the deep-sea mussel Bathymodiolus azoricus assessed using proteomics and transcriptomics

ID

T1

T2

P

T

P

T

TOLL/NF-KB cascade

 Mitogen-activated protein kinase 14

+

/

+

/

 Mitogen-activated protein kinase kinase kinase 4

/

/

/

+

 Mitogen-activated protein kinase kinase kinase kinase 5

/

–

/

+

 Myeloid differentiation primary response protein 88

+

+

/

+

 Dual specificity mitogen-activated protein kinase kinase 1

+

/

/

/

 TLR 20 a

/

/

/

+

 TLR 2

/

–

/

/

 TLR 1

/

+

/

+

 TLR 13

/

+

/

+

 Toll-like receptor 6

/

–

/

/

 Nuclear factor Nf-kappa-b p105 subunit isoform 2

/

/

/

+

 Nf-kappa-b inhibitor-interacting protein

/

–

/

+

Others

 Fibrinogen c domain binding prot 1 like

/

+

/

+

 Suppressor of cytokine signaling

/

–

/

–

 Antimicrobial peptide hydramacin

/

–

/

–

 Lipopolysaccharide-induced tnf-alpha factor

/

+

/

+

 PGRP 3

–

+

–

–

 Complement c1q-like protein 4

–

+

/

+

 Complement c1q tumor necrosis factor-related protein 2

/

+

/

+

 Complement c1q tumor necrosis factor-related protein 3-like

/

+

+

+

 Complement c1q subcomponent subunit b

/

+

/

+

 Complement c1q-like protein 3

/

/

/

+

 C1q domain containing protein 1q2

/

/

+

/

 Complement component 1 q subcomponent-binding mitochondrial-like

/

/

–

/

 Lysozyme 3

/

/

+

+

 Macrophage migration inhibitory factor

/

/

–

+

 C-type lectin domain family 4 member k

/

/

/

+

 C-type lectin domain family 6 member a

/

/

+

+

 C-type lectin domain family 7 member a isoform 7

/

+

/

+

 Collectin-12

/

/

/

+

 Interleukin 17-like

/

/

/

+

  1. P Proteins, T Transcripts, +: up-regulated compared to the natural population, −: Down-regulated, /: No significant differences