Fig. 3

Correlation between bacterial metatranscriptome and host gene expression. Panel a shows the Spearman correlation values between ten Pseudomonas genes (listed below) and eight host genes (listed right). The predicted secondary structures for these host genes are displayed. The detailed annotation and nucleotide sequences of these bacterial genes are listed in Additional file 5. The Kaplan-Meier (KM) plots in panel b categorize the patients into the low and high group based on a median split of expression of the three small RNA genes. The higher the probability on the y-axis, the higher the chance of these patients NOT having metastatic recurrence (MET). The p-value of KM curve was generated by Weighted Cox regression models. The analysis for RNU2-48P and SNORA28 used the Cleveland Clinic Foundation (CCF) cohort [16], and the analysis for SNORA40 used the JHMI cohort [17]