From: A mathematical model as a tool to identify microRNAs with highest impact on transcriptome changes
Features | Me45 Cells | Top rank vs. other miRNA p-value | |||||
---|---|---|---|---|---|---|---|
Average over all miRNAs | Average over top ranked miRNAs | Average over other miRNAs | Me45 | K562 | HCT116+/+ | HCT116−/− | |
Number of total targeted transcripts a | 3711.41 | 5523.86 | 3574.53 | 1.56 × 10 –10 b | 1.00 × 10 –16 b | 3.20 × 10 –09 b | 7.17 × 10 –08 b |
GC content in mature miRNA [%] | 52.60 | 70.72 | 51.23 | 7.95 × 10 -09b | 3.26 × 10 –11 b | 1.35 × 10 –05 b | 0.001 b |
GC content in seed motif [%] | 53.93 | 71.92 | 52.57 | 1.93 × 10 –07 b | 1.23 × 10 –11 b | 8.37 × 10 –05 b | 0.002 b |
GC content in pre-miRNA [%] | 52.90 | 66.44 | 51.88 | 2.55 × 10 –07 b | 1.08 × 10 –08 b | 3.69 × 10 –05 b | 0.004 b |
Number of GC pairs in pre-miRNA | 15.73 | 19.74 | 15.43 | 0.027 b | 0.001 b | 0.005 b | 0.306 |
Number of unpaired fragments in mature double stranded miRNA | 2.60 | 3.14 | 2.57 | 0.019 b | 0.243 | 0.144 | 0.526 |
Length of complementary fragments in pre-miRNA | 5.81 | 4.69 | 5.90 | 0.012 b | 0.042 b | 0.072 | 0.654 |
Length of mature miRNA | 21.61 | 21.14 | 21.65 | 0.031 b | 0.028 b | 0.522 | 0.169 |
Parameter ∆ki | 0.00031 | −0.0039 | −0.000042 | 0.022 b | 0.016 b | 0.047 | 0.103 |
Spearman’s rho in ranking | 0.12 | 0.33 | 0.10 | 7.24 × 10 –20 b | 2.48 × 10 –20 b | 1.80 × 10 –20 b | 4.73 × 10 –20 b |