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Table 4 Properties of the 30 highest-ranked miRNAs compared with the group of all other miRNAs, with Me45 cells as reference

From: A mathematical model as a tool to identify microRNAs with highest impact on transcriptome changes

Features

Me45 Cells

Top rank vs. other miRNA p-value

Average over all miRNAs

Average over top ranked miRNAs

Average over other miRNAs

Me45

K562

HCT116+/+

HCT116−/−

Number of total targeted transcripts a

3711.41

5523.86

3574.53

1.56 × 10 –10 b

1.00 × 10 –16 b

3.20 × 10 –09 b

7.17 × 10 –08 b

GC content in mature miRNA [%]

52.60

70.72

51.23

7.95 × 10 -09b

3.26 × 10 –11 b

1.35 × 10 –05 b

0.001 b

GC content in seed motif [%]

53.93

71.92

52.57

1.93 × 10 –07 b

1.23 × 10 –11 b

8.37 × 10 –05 b

0.002 b

GC content in pre-miRNA [%]

52.90

66.44

51.88

2.55 × 10 –07 b

1.08 × 10 –08 b

3.69 × 10 –05 b

0.004 b

Number of GC pairs in pre-miRNA

15.73

19.74

15.43

0.027 b

0.001 b

0.005 b

0.306

Number of unpaired fragments in mature double stranded miRNA

2.60

3.14

2.57

0.019 b

0.243

0.144

0.526

Length of complementary fragments in pre-miRNA

5.81

4.69

5.90

0.012 b

0.042 b

0.072

0.654

Length of mature miRNA

21.61

21.14

21.65

0.031 b

0.028 b

0.522

0.169

Parameter ∆ki

0.00031

−0.0039

−0.000042

0.022 b

0.016 b

0.047

0.103

Spearman’s rho in ranking

0.12

0.33

0.10

7.24 × 10 –20 b

2.48 × 10 –20 b

1.80 × 10 –20 b

4.73 × 10 –20 b

  1. aAverage of values calculated for each single miRNA, based on targeted motifs obtained as described in Methods
  2. bBoldface numbers indicate statistically significant differences