Fig. 6

Discovered sequence motifs associated with DNA methylation. The first column is the number of de novo motifs and the second column is the motif logo generated by MEME. The third column is the known motifs matched by Tomtom, and the next forth column is the corresponding class and family representing the biological factor species of the known motifs. The p-value is defined as the probability that a random motif of the same width as the target would have an optimal alignment with a match score as good as or better than the target’s. Tomtom estimates the p-value using a null model consisting of sampling motif columns from all the columns in the set of target motifs