A unique insight into the MiRNA profile during genital chlamydial infection

BMC Genomics

Table 2 miRNAs differentially expressed after Chlamydia infection

Week	miR	Fold Change(Log)	P value*	Direction
Week 1	mmu-miR-378b^a	2.91	0.000057	UP
Week 2	mmu-miR-3470b^c	2.93	0.000003	UP
Week 4	mmu-miR-204-5p^a	1.43	0.000276	UP
	mmu-miR-151-5p^b	1.83	0.000292	UP
	mmu-miR-142-3p^a	−1.48	0.000446	DOWN
	mmu-miR-449a-5p^a	−2.07	0.000493	DOWN
Week 8	mmu-miR-378b^a	−4.83	0.000000	DOWN
	mmu-miR-128-3p^b	−2.01	0.000016	DOWN
	mmu-miR-151-5p^b	−1.78	0.000018	DOWN
	mmu-miR-101c^b	−3.20	0.000035	DOWN
	mmu-miR-335-3p^a	2.03	0.000101	UP
	mmu-miR-450b-5p^b	2.11	0.000108	UP
	mmu-miR-195a-3p^b	−2.11	0.000222	DOWN
	mmu-miR-92b-3p^a	1.94	0.000260	UP
	mmu-miR-142-5p^a	−1.92	0.000319	DOWN
	mmu-miR-106a-5p^a	−2.14	0.000438	DOWN
	mmu-miR-690^c	1.67	0.000692	UP
	mmu-miR-148a-3p^a	−1.36	0.001044	DOWN
	mmu-miR-450a-5p^a	2.19	0.001104	UP
	mmu-miR-133b-3p^b	1.63	0.001430	UP
	mmu-miR-92a-3p^a	1.75	0.001695	UP

miRNAs expressed weeks 1, 2, 4 and 8 after infection; ^a miRNAs that have an exact human homolog in miRBase; ^b miRNAs that do not have an exact human homolog in miRBase, but might be different by a few nucleotides, ^c no known human homolog in miRBase. *P-value significance threshold was set at p < 0.05. p-values here were adjusted or controlled by false discovery rate. Positive fold change (log) value indicates upregulation of the expressed miRNA while a negative fold change (log) value indicates downregulation of the expressed miRNA

ISSN: 1471-2164