Table 2 Top ten microbial metabolites ranked based on shared genes with RA (166 genes from combined resources were used). SCFAs are highlighted
Metabolite | Targeted RA Genes | Targeted RA Genes |
|---|---|---|
Acetic acid | 30 | ACP5, ANKRD55, BAG6, BLK, CDK6, CIITA, CLYBL, CSF2 GABARAPL3, GATA3, GRM5, HLA-DQA1, HLA-DQB1 IL10, IL2, IL2RB, IL6, KCNIP4, MECP2, NFKBIE, NOTCH4 PPIL4, RAD51B, REL, SUOX, TEC, TXNDC11, TYK2 UTS2, ZNF774 |
Butyric acid | 13 | ACOXL, CDK6, CLYBL, CSF2, GRM5, IL10, IL2, IL6 MECP2, PRKCB, PRKCH, STAT4, UTS2 |
Acetaldehyde | 13 | CSF2, DPP4, HLA-DRB1, IL6, KCNIP4, PADI4, PPIL4 PRKCB, RAD51B, STAG1, TRNT1, TXNDC11, ZNF774 |
Methane | 12 | BAG6, CSF2, CTLA4, EOMES, GATA3, GRM5, IFNAR1 IL10, IL2, IL6, PTPN22, STAG1 |
mannitol | 10 | ARHGEF3, BAG6, BLK, CLYBL, IL6, LRRC18, SLC22A4 TEC, TNFAIP3, TYK2 |
1-butanol | 8 | ANKRD55, BAG6, IL2, IL6, NFKBIE, NOTCH4 PTPN2, PTPN22 |
Isopropyl alcohol | 8 | ACP5, CLYBL, GCH1, IL10, IL6, KCNIP4 PTPN2, PTPN22 |
Propionic acid | 7 | GATA3, GCH1, GRM5, IL10, IL6, SLC22A4, UTS2 |
Succinic acid | 6 | BAG6, CCL21, CCR6, CXCR5, OS9, PPIL4 |
Isobutyric acid | 6 | CLYBL, GCH1, NFKBIE, REL |