Table 6 Top 10 shared genetic pathways between RA and other SCFAs (acetic acid, propionic acid) and methane (top one ranked metabolite)
RA ∩ Acetic acid | RA ∩ Propionic acid | RA ∩ Methane |
|---|---|---|
IL 2 signaling pathway | Interleukin-6 signaling | Regulation of hematopoiesis by cytokines |
Trka Receptor Signaling Pathway | IL 5 Signaling Pathway | Cytokine Network |
IL 5 Signaling Pathway | Antigen Dependent B Cell Activation | Dendritic cells in regulating TH1 and TH2 Development |
Cadmium induces DNA synthesis and proliferation in macrophages | Organic cation/anion/zwitterion transport | Antigen Dependent B Cell Activation |
Role of ERBB2 in Signal Transduction and Oncology | Dendritic cells in regulating TH1 and TH2 Development | Cytokines and Inflammatory Response |
Interleukin-6 signaling | Trafficking of GluR2-containing AMPA receptors | IL 17 Signaling Pathway |
IL2 signaling events mediated by STAT5 | Regulation of hematopoiesis by cytokines | IL 2 signaling pathway |
RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage | Role of ERBB2 in Signal Transduction and Oncology | STAT3 Pathway |
IL2 signaling events mediated by PI3K | Folate biosynthesis | Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor |
Interleukin 13 (IL-13) Pathway | Cytokine Network | GATA3 participate in activating the Th2 cytokine genes expression |