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Table 2 Selected enriched KEGG pathways

From: Alterations in tissue microRNA after heat stress in the conscious rat: potential biomarkers of organ-specific injury

Condition Pathway # of genes p-value Benjamini corrected p-value
Heart 48 h - Injured Biosynthesis of antibiotics 62 < 0.001 < 0.001
Metabolic pathways 237 < 0.001 < 0.001
Insulin resistance 36 < 0.001 < 0.001
cGMP-PKG signaling pathway 48 < 0.001 < 0.001
Fatty acid metabolism 23 < 0.001 < 0.001
PI3K-Akt signaling pathway 78 < 0.001 < 0.001
Leukocyte transendothelial migration 37 < 0.001 < 0.001
Carbon metabolism 37 < 0.001 < 0.001
Citrate cycle (TCA cycle) 16 < 0.001 < 0.001
Focal adhesion 53 < 0.001 < 0.001
Arrhythmogenic right ventricular cardiomyopathy (ARVC) 23 < 0.001 0.001
PPAR signaling pathway 23 < 0.001 0.004
Protein digestion and absorption 25 < 0.001 0.005
Hypertrophic cardiomyopathy (HCM) 23 0.001 0.006
Dilated cardiomyopathy 22 0.003 0.021
Liver Tc,max Endocytosis 4 0.016 0.537
Kidney 48 h - Injured Complement and coagulation cascades 14 < 0.001 < 0.001
Cell cycle 16 < 0.001 < 0.001
p53 signaling pathway 9 < 0.001 0.003
Bile secretion 9 < 0.001 0.003
PPAR signaling pathway 9 < 0.001 0.004
FoxO signaling pathway 10 0.001 0.037
Progesterone-mediated oocyte maturation 8 0.001 0.043
MicroRNAs in cancer 9 0.006 0.141
Small cell lung cancer 7 0.006 0.133
Carbohydrate digestion and absorption 5 0.007 0.145
Biosynthesis of unsaturated fatty acids 4 0.017 0.265
Lung Tc,max TNF signaling pathway 4 0.026 0.974
Pathways in cancer 7 0.029 0.863
NOD-like receptor signaling pathway 3 0.043 0.866
Lung 48 h - Injured Calcium signaling pathway 8 0.001 0.145
PPAR signaling pathway 5 0.005 0.266
Oocyte meiosis 5 0.016 0.499
p53 signaling pathway 4 0.024 0.548
Signaling pathways regulating pluripotency of stem cells 5 0.035 0.610
Protein digestion and absorption 4 0.044 0.627
Neuroactive ligand-receptor interaction 7 0.044 0.571
Tyrosine metabolism 3 0.047 0.542
  1. The top ten and selected enriched KEGG pathways for each condition are shown with p-values and adjusted p-values. The number of genes listed are unique genes that are targets of the differentially expressed miRNA in that condition and contribute to the enrichment of the pathway. The complete list of enriched pathways are listed in Additional File 4