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Table 2 Selected enriched KEGG pathways

From: Alterations in tissue microRNA after heat stress in the conscious rat: potential biomarkers of organ-specific injury

Condition

Pathway

# of genes

p-value

Benjamini corrected p-value

Heart 48 h - Injured

Biosynthesis of antibiotics

62

< 0.001

< 0.001

Metabolic pathways

237

< 0.001

< 0.001

Insulin resistance

36

< 0.001

< 0.001

cGMP-PKG signaling pathway

48

< 0.001

< 0.001

Fatty acid metabolism

23

< 0.001

< 0.001

PI3K-Akt signaling pathway

78

< 0.001

< 0.001

Leukocyte transendothelial migration

37

< 0.001

< 0.001

Carbon metabolism

37

< 0.001

< 0.001

Citrate cycle (TCA cycle)

16

< 0.001

< 0.001

Focal adhesion

53

< 0.001

< 0.001

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

23

< 0.001

0.001

PPAR signaling pathway

23

< 0.001

0.004

Protein digestion and absorption

25

< 0.001

0.005

Hypertrophic cardiomyopathy (HCM)

23

0.001

0.006

Dilated cardiomyopathy

22

0.003

0.021

Liver Tc,max

Endocytosis

4

0.016

0.537

Kidney 48 h - Injured

Complement and coagulation cascades

14

< 0.001

< 0.001

Cell cycle

16

< 0.001

< 0.001

p53 signaling pathway

9

< 0.001

0.003

Bile secretion

9

< 0.001

0.003

PPAR signaling pathway

9

< 0.001

0.004

FoxO signaling pathway

10

0.001

0.037

Progesterone-mediated oocyte maturation

8

0.001

0.043

MicroRNAs in cancer

9

0.006

0.141

Small cell lung cancer

7

0.006

0.133

Carbohydrate digestion and absorption

5

0.007

0.145

Biosynthesis of unsaturated fatty acids

4

0.017

0.265

Lung Tc,max

TNF signaling pathway

4

0.026

0.974

Pathways in cancer

7

0.029

0.863

NOD-like receptor signaling pathway

3

0.043

0.866

Lung 48 h - Injured

Calcium signaling pathway

8

0.001

0.145

PPAR signaling pathway

5

0.005

0.266

Oocyte meiosis

5

0.016

0.499

p53 signaling pathway

4

0.024

0.548

Signaling pathways regulating pluripotency of stem cells

5

0.035

0.610

Protein digestion and absorption

4

0.044

0.627

Neuroactive ligand-receptor interaction

7

0.044

0.571

Tyrosine metabolism

3

0.047

0.542

  1. The top ten and selected enriched KEGG pathways for each condition are shown with p-values and adjusted p-values. The number of genes listed are unique genes that are targets of the differentially expressed miRNA in that condition and contribute to the enrichment of the pathway. The complete list of enriched pathways are listed in Additional File 4