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Fig. 1 | BMC Genomics

Fig. 1

From: Proteome profiling of triple negative breast cancer cells overexpressing NOD1 and NOD2 receptors unveils molecular signatures of malignant cell proliferation

Fig. 1

Volcano plots showing detected peptides (represented by annotated Entrez gene names) in samples overexpressing NOD1 (HS578T/NOD1) (a) and NOD2 (HS578T/NOD2) (b). Visualization in Spotfire® (TIBCO® Software). Thresholds for differentially expressed gene inclusion were established at + 1 or − 1 log2 fold-change (x axis), from the unmodified HS578T cells (P). Similarly, a threshold for inclusion was set at p-value 0.05 (y axis). Circles representing each identified protein are colored according to Standard Error (SE) calculated by MSstats and circle size according to the number of peptides identified in each protein. Lists of differentially regulated proteins in HS578T/NOD1 (c) and HS578T/NOD2 (d) cell populations. Inclusion criteria: log2 fold-change ≥ + 1 or ≤ − 1 and p-value ≤0.05. Proteins with log2 fold-change ≥ + 0.5 or ≤ − 0.5 and p-value ≤0.01 were also included in the lists. Proteins are ranked and color-coded according to their log2-fold-change relative to their expression in the unmodified HS578T cells (P). For each protein, Entrez gene name, Uniprot accession number, protein name and fold change in both experimental groups are reported. Top 30 differentially expressed proteins are shown, complete lists are available as Additional file 1: Figure S1. Color-coding carried out using MS Office Excel, Red: upregulated. Blue: downregulated

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