Risk-modeling of dog osteosarcoma genome scans shows individuals with Mendelian-level polygenic risk are common

BMC Genomics

Table 1 Multiple Logistic Regression model selection summary

	Cohort	Parameters	Max-rescaled R²	AIC (No Covariates)	AIC (With Covariates)	Terms in model	Hosmer & Lameshow Goodness of fit test
Stepwise forward selection	Generalized	14	0.377	645.95	538.75	BICF2P1225386, BICF2S23516022, BICF2P1194727, BICF2P1090686, BICF2P133066, BICF2S23118341, BICF2P66597, TIGRP2P200071, BICF2G630813090, BICF2S23533459, BICF2G63051809, BICF2G63095567, BICF2S23712115, BICF2P92014	0.209
	Greyhound	10	0.542	310.90	228.25	BICF2P1194727, BICF2P1421479, BICF2P133066, BICF2S23118341, BICF2P66597, BICF2G630418573, BICF2G63051809, BICF2G63095567, TIGRP2P331221, BICF2S23712115	0.8352
	Irish Wolfhound	4	0.375	173.18	147.74	BICF2P1225386, BICF2P1466354, BICF2G630590368, BICF2P1129874	0.4206
	Rottweiler	6	0.741	153.99	85.29	BICF2P1115364, BICF2P341331, BICF2G63095567, BICF2S23712115, TIGRP2P407733, BICF2P92014	0.6255
LASSO	Generalized	36	0.576	491.61	425.69	All terms were included by the method including cohort and sex	0.0217
	Greyhound	17	0.632	270.80	205.21	BICF2S23516022, TIGRP2P45171, BICF2P1194727, BICF2P1090686, BICF2P1421479, BICF2P133066, BICF2S23118341, BICF2P66597, BICF2G630418573, TIGRP2P215623, BICF2G630813090, BICF2G63051809, BICF2S23637753, BICF2S23325120, BICF2G63095567, TIGRP2P331221, BICF2S23712115	0.1729
	Irish Wolfhound	3	0.242	177.86	165.00	BICF2P1225386, BICF2S23746532, BICF2P1466354	0.0567
	Rottweiler	12	0.900	128.90	70.08	BICF2P1164085, BICF2P1115364, BICF2P1210630, BICF2P411325, BICF2P341331, TIGRP2P200071, BICF2S23533459, TIGRP2P286750, BICF2G63095567, BICF2S23712115, TIGRP2P407733, BICF2P92014	0.5324

ISSN: 1471-2164