TY - JOUR AU - Shamanskiy, Viktor N. AU - Timonina, Valeria N. AU - Popadin, Konstantin Yu. AU - Gunbin, Konstantin V. PY - 2019 DA - 2019/05/08 TI - ImtRDB: a database and software for mitochondrial imperfect interspersed repeats annotation JO - BMC Genomics SP - 295 VL - 20 IS - 3 AB - Mitochondria is a powerhouse of all eukaryotic cells that have its own circular DNA (mtDNA) encoding various RNAs and proteins. Somatic perturbations of mtDNA are accumulating with age thus it is of great importance to uncover the main sources of mtDNA instability. Recent analyses demonstrated that somatic mtDNA deletions depend on imperfect repeats of various nature between distant mtDNA segments. However, till now there are no comprehensive databases annotating all types of imperfect repeats in numerous species with sequenced complete mitochondrial genome as well as there are no algorithms capable to call all types of imperfect repeats in circular mtDNA. SN - 1471-2164 UR - https://doi.org/10.1186/s12864-019-5536-1 DO - 10.1186/s12864-019-5536-1 ID - Shamanskiy2019 ER -