TY - JOUR AU - Ivanisenko, Nikita V. AU - Buchbinder, Jörn H. AU - Espe, Johannes AU - Richter, Max AU - Bollmann, Miriam AU - Hillert, Laura K. AU - Ivanisenko, Vladimir A. AU - Lavrik, Inna N. PY - 2019 DA - 2019/05/08 TI - Delineating the role of c-FLIP/NEMO interaction in the CD95 network via rational design of molecular probes JO - BMC Genomics SP - 293 VL - 20 IS - 3 AB - Structural homology modeling supported by bioinformatics analysis plays a key role in uncovering new molecular interactions within gene regulatory networks. Here, we have applied this powerful approach to analyze the molecular interactions orchestrating death receptor signaling networks. In particular, we focused on the molecular mechanisms of CD95-mediated NF-κB activation and the role of c-FLIP/NEMO interaction in the induction of this pathway. SN - 1471-2164 UR - https://doi.org/10.1186/s12864-019-5539-y DO - 10.1186/s12864-019-5539-y ID - Ivanisenko2019 ER -