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Table 1 Genes differentially expressed in ISIAH and WAG brain stems and referred to in Databases as associated with blood pressure regulation and hypertension

From: The differences in brain stem transcriptional profiling in hypertensive ISIAH and normotensive WAG rats

Gene symbol

Gene_ID

log2

(fold_change) ISIAH/WAG

Gene definition

Rat Genome Database

Aoc3*

29473

−1.40

amine oxidase, copper containing 3 (vascular adhesion protein 1)

Cbs*

24250

0.54

cystathionine beta synthase

Chi3l1*

89824

−1.36

chitinase 3-like 1 (cartilage glycoprotein-39)

Col1a1*

29393

−0.73

collagen, type I, alpha 1

Col3a1*

84032

−1.08

collagen, type III, alpha 1

Cyp11a1*

29680

2.55

cytochrome P450, family 11, subfamily a, polypeptide 1

Cyp11b1

500892

1.12

cytochrome P450, family 11, subfamily b, polypeptide 1

Cyp11b2*

24294

1.12

cytochrome P450, family 11, subfamily b, polypeptide 2

Ephx2* #

65030

4.23

epoxide hydrolase 2, cytoplasmic

F2r* #

25439

0.81

coagulation factor II (thrombin) receptor

Fn1*

25661

−1.30

fibronectin 1

Gstm2*

24424

−1.10

glutathione S-transferase mu 2

Gucy1a3*

497757

−0.69

guanylate cyclase 1, soluble, alpha 3

Igfbp2*

25662

−0.51

insulin-like growth factor binding protein 2

Il18* #

29197

−1.29

interleukin 18

Npr1

24603

−0.61

natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)

Ptgds*

25526

−0.74

prostaglandin D2 synthase (brain)

Tlr3*

364594

0.96

toll-like receptor 3

DAVID

Acta2*

81633

−0.74

smooth muscle alpha-actin

Hba2

360504

0.58

hemoglobin alpha 2 chain

P2rx4*

29659

−0.88

purinergic receptor P2X, ligand-gated ion channel 4

Sult1a1*

83783

−0.85

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

  1. Genes associated with *- central nervous system diseases; # - brain ischemia;
  2. ISIAH and WAG – rat strains used in the study