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Table 4 The top 50 DEGs making the most significant contribution to the inter-strain differences

From: The differences in brain stem transcriptional profiling in hypertensive ISIAH and normotensive WAG rats

Gene symbol Gene ID r log2 (fold_change) ISIAH/WAG Gene definition
Mpeg1 64552 −0.998 −3.11 macrophage expressed 1
RT1-A2 24974 −0.995 −1.94 RT1 class Ia, locus A2
Gstm4 499689 −0.994 −1.95 glutathione S-transferase mu 4
Mettl24 499465 −0.993 expressed only in WAG rat strain methyltransferase like 24
Grm2 24415 −0.993 −2.74 glutamate receptor, metabotropic 2
Rufy1 360521 −0.992 −0.62 RUN and FYVE domain containing 1
LOC688584 688584 −0.992 expressed only in WAG rat strain similar to BCL2/adenovirus E1B 19 kDa-interacting protein 3-like
RT1-S3 294228 −0.992 −2.02 RT1 class Ib, locus S3
Slc25a48 361206 −0.991 −1.77 solute carrier family 25, member 48
LOC100360731 100360731 −0.991 expressed only in WAG rat strain SNRPN upstream reading frame protein-like
LOC678760 678760 −0.989 expressed only in WAG rat strain dipeptidyl peptidase 3-like
Eif3c 293484 −0.988 −0.52 eukaryotic translation initiation factor 3, subunit C
Fn1 25661 −0.986 −1.30 fibronectin 1
Cryab 25420 −0.986 −0.87 crystallin, alpha B
Abca8a 303638 −0.986 −0.85 ATP-binding cassette, subfamily A (ABC1), member 8a
Nptx2 288475 −0.984 −1.35 neuronal pentraxin II
Chi3l1* 89824 −0.983 −1.36 chitinase 3-like 1 (cartilage glycoprotein-39)
Ly75 499800 −0.983 −0.79 lymphocyte antigen 75
Mx2 286918 −0.981 −1.49 myxovirus (influenza virus) resistance 2
Sdf2l1 680945 −0.981 −0.96 stromal cell-derived factor 2-like 1
Grifin 117130 −0.980 −5.85 galectin-related inter-fiber protein
Pld5 289270 −0.978 −0.99 phospholipase D family, member 5
Tmem119 304581 −0.977 −1.43 transmembrane protein 119
Lcat 24530 −0.976 −1.20 lecithin cholesterol acyltransferase
Pla2g3 289733 −0.976 −0.84 phospholipase A2, group III
Pnpla1 361812 −0.976 −2.94 patatin-like phospholipase domain containing 1
Flnc 362332 −0.975 −0.64 filamin C, gamma
Neu4 316642 −0.973 −0.96 sialidase 4
F2r* 25439 0.973 0.81 coagulation factor II (thrombin) receptor
Enpp6 306460 0.973 1.53 ectonucleotide pyrophosphatase/phosphodiesterase 6
LOC100134871 100134871 0.977 3.65 beta globin minor gene
LOC100362027 100362027 0.979 expressed only in ISIAH rat strain ribosomal protein L30-like
Abhd1 313917 0.980 1.97 abhydrolase domain containing 1
RGD1564278 312994 0.980 expressed only in ISIAH rat strain RNA-binding protein with serine-rich domain 1-like
Golm1 680692 0.980 0.63 Golgi membrane protein 1-like
Leprel4 59101 0.981 1.00 leprecan-like 4
RGD1565131 498143 0.981 7.05 60S ribosomal protein L15-like
LOC688504 688504 0.981 expressed only in ISIAH rat strain 60S ribosomal protein L28 pseudogene
Retsat 246298 0.982 1.86 retinol saturase (all trans retinol 13,14 reductase)
Ephx2* 65030 0.982 4.23 epoxide hydrolase 2, cytoplasmic
Ndufa10l1 316632 0.983 1.63 NADH dehydrogenase (ubiquinone 1 alpha subcomplex 10-like 1
Evc 289712 0.986 1.03 Ellis van Creveld syndrome homolog (human)
Sc5dl 114100 0.987 1.24 sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S, cerevisiae)-like
Sacm2l-ps3 415066 0.988 expressed only in ISIAH rat strain Sacm2l-ps3 pseudogene
Tlr3* 364594 0.989 0.96 toll-like receptor 3
Fhit 60398 0.991 2.12 fragile histidine triad gene
Abcg2 312382 0.991 1.84 ATP-binding cassette, subfamily G (WHITE), member 2
LOC685744 685744 0.993 expressed only in ISIAH rat strain hypothetical protein LOC685744
LOC360998 360998 0.998 0.90 hypothetical LOC360998
Fhad1 500577 0.999 2.31 forkhead-associated (FHA) phosphopeptide binding domain 1
  1. *- genes associated with hypertension; ISIAH and WAG – rat strains used in the study
  2. r - correlation coefficient between gene expression and PLS-DA Axis 1