Table 4 The top 50 DEGs making the most significant contribution to the inter-strain differences
Gene symbol | Gene ID | r | log2 (fold_change) ISIAH/WAG | Gene definition |
|---|---|---|---|---|
Mpeg1 | 64552 | −0.998 | −3.11 | macrophage expressed 1 |
RT1-A2 | 24974 | −0.995 | −1.94 | RT1 class Ia, locus A2 |
Gstm4 | 499689 | −0.994 | −1.95 | glutathione S-transferase mu 4 |
Mettl24 | 499465 | −0.993 | expressed only in WAG rat strain | methyltransferase like 24 |
Grm2 | 24415 | −0.993 | −2.74 | glutamate receptor, metabotropic 2 |
Rufy1 | 360521 | −0.992 | −0.62 | RUN and FYVE domain containing 1 |
LOC688584 | 688584 | −0.992 | expressed only in WAG rat strain | similar to BCL2/adenovirus E1B 19 kDa-interacting protein 3-like |
RT1-S3 | 294228 | −0.992 | −2.02 | RT1 class Ib, locus S3 |
Slc25a48 | 361206 | −0.991 | −1.77 | solute carrier family 25, member 48 |
LOC100360731 | 100360731 | −0.991 | expressed only in WAG rat strain | SNRPN upstream reading frame protein-like |
LOC678760 | 678760 | −0.989 | expressed only in WAG rat strain | dipeptidyl peptidase 3-like |
Eif3c | 293484 | −0.988 | −0.52 | eukaryotic translation initiation factor 3, subunit C |
Fn1 | 25661 | −0.986 | −1.30 | fibronectin 1 |
Cryab | 25420 | −0.986 | −0.87 | crystallin, alpha B |
Abca8a | 303638 | −0.986 | −0.85 | ATP-binding cassette, subfamily A (ABC1), member 8a |
Nptx2 | 288475 | −0.984 | −1.35 | neuronal pentraxin II |
Chi3l1* | 89824 | −0.983 | −1.36 | chitinase 3-like 1 (cartilage glycoprotein-39) |
Ly75 | 499800 | −0.983 | −0.79 | lymphocyte antigen 75 |
Mx2 | 286918 | −0.981 | −1.49 | myxovirus (influenza virus) resistance 2 |
Sdf2l1 | 680945 | −0.981 | −0.96 | stromal cell-derived factor 2-like 1 |
Grifin | 117130 | −0.980 | −5.85 | galectin-related inter-fiber protein |
Pld5 | 289270 | −0.978 | −0.99 | phospholipase D family, member 5 |
Tmem119 | 304581 | −0.977 | −1.43 | transmembrane protein 119 |
Lcat | 24530 | −0.976 | −1.20 | lecithin cholesterol acyltransferase |
Pla2g3 | 289733 | −0.976 | −0.84 | phospholipase A2, group III |
Pnpla1 | 361812 | −0.976 | −2.94 | patatin-like phospholipase domain containing 1 |
Flnc | 362332 | −0.975 | −0.64 | filamin C, gamma |
Neu4 | 316642 | −0.973 | −0.96 | sialidase 4 |
F2r* | 25439 | 0.973 | 0.81 | coagulation factor II (thrombin) receptor |
Enpp6 | 306460 | 0.973 | 1.53 | ectonucleotide pyrophosphatase/phosphodiesterase 6 |
LOC100134871 | 100134871 | 0.977 | 3.65 | beta globin minor gene |
LOC100362027 | 100362027 | 0.979 | expressed only in ISIAH rat strain | ribosomal protein L30-like |
Abhd1 | 313917 | 0.980 | 1.97 | abhydrolase domain containing 1 |
RGD1564278 | 312994 | 0.980 | expressed only in ISIAH rat strain | RNA-binding protein with serine-rich domain 1-like |
Golm1 | 680692 | 0.980 | 0.63 | Golgi membrane protein 1-like |
Leprel4 | 59101 | 0.981 | 1.00 | leprecan-like 4 |
RGD1565131 | 498143 | 0.981 | 7.05 | 60S ribosomal protein L15-like |
LOC688504 | 688504 | 0.981 | expressed only in ISIAH rat strain | 60S ribosomal protein L28 pseudogene |
Retsat | 246298 | 0.982 | 1.86 | retinol saturase (all trans retinol 13,14 reductase) |
Ephx2* | 65030 | 0.982 | 4.23 | epoxide hydrolase 2, cytoplasmic |
Ndufa10l1 | 316632 | 0.983 | 1.63 | NADH dehydrogenase (ubiquinone 1 alpha subcomplex 10-like 1 |
Evc | 289712 | 0.986 | 1.03 | Ellis van Creveld syndrome homolog (human) |
Sc5dl | 114100 | 0.987 | 1.24 | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S, cerevisiae)-like |
Sacm2l-ps3 | 415066 | 0.988 | expressed only in ISIAH rat strain | Sacm2l-ps3 pseudogene |
Tlr3* | 364594 | 0.989 | 0.96 | toll-like receptor 3 |
Fhit | 60398 | 0.991 | 2.12 | fragile histidine triad gene |
Abcg2 | 312382 | 0.991 | 1.84 | ATP-binding cassette, subfamily G (WHITE), member 2 |
LOC685744 | 685744 | 0.993 | expressed only in ISIAH rat strain | hypothetical protein LOC685744 |
LOC360998 | 360998 | 0.998 | 0.90 | hypothetical LOC360998 |
Fhad1 | 500577 | 0.999 | 2.31 | forkhead-associated (FHA) phosphopeptide binding domain 1 |