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Fig. 3 | BMC Genomics

Fig. 3

From: A modular analysis of microglia gene expression, insights into the aged phenotype

Fig. 3

Module markers can be used in a combinatorial code to distinguish between inflammatory states. a Differential expression of canonical M1 (Tnf, Il1b) markers upon stimulation with inflammatory stimuli. Log2 fold change relative to control. Error bars represent standard deviation. *p < 0.05. b Heatmap of module eigengenes for inflammatory stimuli. Only modules active in at least one condition are shown. Gray mask = n.s. compared to control, *p < 0.05. c Differential expression of module markers for BR_turquoise (Ifit3), PI_turquoise (Naaa), CY_turquoise (Clec4e), YE_turquoise (Irak3) modules in 24 h stimulus conditions. Log2 fold change relative to control. Error bars represent standard deviation. *p < 0.05. d Combinatorial code of hub gene induction for five different inflammatory stimuli. e Differential expression of module markers for BR_turquoise (Ifit3), PI_turquoise (Naaa), CY_turquoise (Clec4e), YE_turquoise (Irak3) modules in 72 h stimulus conditions. Log2 fold change relative to control. Error bars represent standard deviation. *p < 0.05. f Comparison of empirical and predicted induction of hub genes

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