Fig. 2

Embryonic transcriptomic profiles. a) Principle Component Analysis (PCA) of Mas5 normalised expression values across the human embryonic developmental stages, four oocytes (orange), four 4-cell embryos (red), three whole 8-cell embryos (green), eight 8-cell blastomeres (blue) and four blastocysts (purple). Ellipsoids represent variation within a specific developmental stage. b) Heat map of change point matrix for developmental series displayed in panel A. Red represents increased expression and blue decreased expression. c) Overlap of network modules across human embryo development. The top 15 modules are extracted from each developmental stage networks and listed in hierarchical order from (1st) most central in the network to (15th) less centrally connected in the network. The gene labelled on the module represents the most centrally connected gene within the module. Blue lines indicate modules which have > 2 shared members between the different developmental stages and the thicker the line the greater the number of shared genes. Modules outlined in red have no shared central elements with the following or preceding developmental stage