Fig. 6

Pan-genome analysis of L. interrogans (n = 97) using the BPGA pipeline. The power and exponential law equations were used to create pan- and core-genome curves of L. interrogans (panel a). The COG categories distribution of core, accessory and strain-specific genes in 97 L. interrogans strains are shown in panel b, and according to Heap’s law the Leptospira genome was predicted to be open. The COG categories are denoted as follows: D (Cell cycle control, cell division, chromosome partitioning), M (Cell wall/membrane/envelope biogenesis), N (Cell motility), O (Posttranslational modification, protein turnover, chaperones), T (Signal transduction mechanisms), U (Intracellular trafficking, secretion, and vesicular transport), V (Defense mechanisms), J (Translation, ribosomal structure and biogenesis), K (Transcription), L (Replication, recombination and repair), C (Energy production and conversion), G (Carbohydrate transport and metabolism), E (Amino acid transport and metabolism), F (Nucleotide transport and metabolism), H (Coenzyme transport and metabolism), I (Lipid transport and metabolism), Q (Secondary metabolites biosynthesis, transport and catabolism), P (Inorganic ion transport and metabolism), R (General function prediction only), and S (Function unknown)