Fig. 7

Circular genome map of L. interrogans serovar Lai strain 56601 and the other 13 representative strains studied, with the location of 101 predicted virulence genes under positive selection marked. Comparative sequence analysis was performed with BRIG [76] using L. interrogans strain 56601 as a reference (thick black innermost ring) against other representative related L. interrogans strains. The second inner ring indicates GC contents (black color) followed by the GC skew (purple and green colors). Each colored ring shows the host origin in each strain of chromosomal DNA of Leptospira presented as follows: magenta for dogs, blue for pigs, cyan for cattle and light-green for humans. The outermost labels show the location of 101 predicted virulence genes under positive selection in L. interrogans. The intensity of the ring color represents the percentage of nucleotide identity from 50 to 90