Fig. 3

Limited overlap in effects of PPARα and CREB3L3 deficiency on hepatic gene expression in the fasted state. a Venn diagram showing overlap in downregulated genes in PPARα−/−, CREB3L3−/−, and combined PPARα/CREB3L3−/− mice, in comparison with wild-type mice (IBMT P-value< 0.001). b Correlation plot showing gene expression changes in CREB3L3−/− mice in relation to wild-type mice (x-axis) and in PPARα−/− mice in relation to wild-type mice (y-axis) (expressed as signal log ratio, SLR). c Comparative gene expression analysis in liver of wild-type, PPARα−/−, CREB3L3−/−, and combined PPARα/CREB3L3−/− mice after 16-h fast. For comparison, gene expression changes in mouse liver after PPARα activation by 5-day treatment with the agonist Wy-14,643 are shown (GSE8316) [51], as well as gene expression changes in mouse liver after adenoviral-mediated over expression of CREB3L3. Asterisk indicates significantly different from control conditions according to IBMT P-value< 0.001. The 34 genes shown are the commonly downregulated genes in livers of PPARα−/−, CREB3L3−/−, and PPARα/CREB3L3−/− mice in the fasted state (IBMT P-value< 0.001)