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Fig. 6 | BMC Genomics

Fig. 6

From: Transcriptional profiling of PPARα−/− and CREB3L3−/− livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα

Fig. 6

PPARα and CREB3L3 regulate distinct pathways in the liver in the fasted state. a Top 10 downregulated genesets in liver of PPARα−/− compared with wild-type mice, determined by gene set enrichment analysis. b Top 10 downregulated genesets in liver of CREB3L3−/− compared with wild-type mice, determined by gene set enrichment analysis. Genesets were ranked according to normalized enrichment score (NES). c Venn diagram showing overlap in downregulated genesets (FDR q-value< 0.1) in PPARα−/−, CREB3L3−/−, and combined PPARα/CREB3L3−/− mice, in comparison with wild-type mice. d Top 20 downregulated gene sets in liver of combined PPARα/CREB3L3−/− mice compared with wild-type mice, determined by gene set enrichment analysis and ranked according to NES (purple). The NES of the same genesets for the comparison between wild-type and PPARα−/− (red) or CREB3L3−/− (blue) mice is shown as well

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BMC Genomics

ISSN: 1471-2164

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