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Fig. 7 | BMC Genomics

Fig. 7

From: Transcriptional profiling of PPARα−/− and CREB3L3−/− livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα

Fig. 7

Effect of single and combined PPARα and CREB3L3 deficiency on metabolic parameters. PPARα−/−, CREB3L3−/− and combined PPARα/CREB3L3−/− mice were subjected to a 4 day ketogenic diet. a Bodyweight before the ketogenic diet. WT, n = 15; CREB3L3−/−, n = 12; PPARα−/−, n = 9; PPARα/CREB3L3−/−, n = 10. b Percentage bodyweight loss caused by the ketogenic diet. WT, n = 15; CREB3L3−/−, n = 12; PPARα−/−, n = 10; PPARα/CREB3L3−/−, n = 10. c Liver weight as percentage of total bodyweight. WT, n = 15; CREB3L3−/−, n = 12; PPARα−/−, n = 9; PPARα/CREB3L3−/−, n = 10. d Plasma alanine aminotransferase activity. WT, n = 15; CREB3L3−/−, n = 12; PPARα−/−, n = 5; PPARα/CREB3L3−/−, n = 6. e Hepatic triglycerides. WT, n = 10; CREB3L3−/−, n = 7; PPARα−/−, n = 5; PPARα/CREB3L3−/−, n = 6. f Plasma triglycerides. WT, n = 10; CREB3L3−/−, n = 7; PPARα−/−, n = 5; PPARα/CREB3L3−/−, n = 5. g Plasma Fibroblast Growth Factor 21. WT, n = 9; CREB3L3−/−, n = 7; PPARα−/−, n = 9; PPARα/CREB3L3−/−, n = 5. Error bars represent SEM. Asterisk indicates significant effect of CREB3L3 deficiency in wild-type mice (blue vs. white bar) and in PPARα mice (purple vs red bar) according to Student’s t-test (*P < 0.05, **P < 0.01, ***P < 0.001). Pound sign indicates significant effect of PPARα deficiency in wild-type mice (red vs. white bar) and in CREB3L3 mice (purple vs. blue bar) according to Student’s t-test (#P < 0.05, ##P < 0.01, ###P < 0.001)

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