Fig. 4

a. Organization of homologs of the endocrocin biosynthetic gene cluster in Aspergillus species, FIESC 28 and Pestalotiopsis fici. Blue arrows represent homologous genes present in at least two fungi. Direction of arrows indicate direction of transcription. Abbreviations for gene/protein functions are as follows: AO, anthrone oxidase; TE, metallo-β-lactamase type thioesterase (MβL-TE); PKS, polyketide synthase; TF, = transcription factor, UN, gene of unknown function. The numbers in blue arrows indicate homologs. Black arrows indicate genes that are considered part of the biosynthetic cluster in the respective fungi but that were not present in FIESC 28. b. Proposed biosynthetic pathway for endocrocin anthrone in FIESC 28 and for endocrocin in the other fungi