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Table 2 Genomic regions associated with milk fatty acid traits in the multi-population analysis and suggested candidate genes

From: Multi-population GWAS and enrichment analyses reveal novel genomic regions and promising candidate genes underlying bovine milk fatty acid composition

Regiona

Start (Mbp)

End (Mbp)

Traits associated (and % of explained genetic variance)

Candidate genes

1a

19.92

19.93

C16:0(3.1)

 

1b

101.0

101.0

C18 index(2.8)

 

1c

141.3

142.5

C15:0(3.9)

 

2a

12.5

19.8

C8:0(3.7), C10:0(3.0)

OSBPL6, AGPS

2b

54.9

59.8

C14:1(1.6), C16:0(3.6), C16:1(2.1), C14 index(1.5)

 

2c

64.1

67.8

C16:1(2.3), C16 index(2.3)

 

2d

106.5

135.6

C12:0(2.5), C15:0(5.6), C16:0(2.8), C18:1c9(3.8)

MOGAT1, FABP3, MECR

3

116.2

119.4

C18:3n3(4.3), CLA(3.2)

PRLH

4

15.59

15.6

C15:0(5.2)

 

5a

10.33

10.36

C15:0(9.0)

 

5b

65.7

82.8

C8:0(3.9), C10:0(2.5)

CHPT1

5c

87.4

99.0

C8:0(4.3), C10:0(3.2), C12:0(2.6), C14:1(1.7), C16:0(2.7), C16:1(2.1), C18:1c9(5.6), CLA(3.2), C14 index(2.4), C16 index(4.9)

MGST1, PLBD1, LRP6

6

41.4

41.4

C18 index(2.9)

 

7a

14.6

15.5

C8:0(3.3), C10:0(2.2)

 

7b

78.4

78.4

C18:2n6(3.3)

 

7c

81.6

83.2

C12:0(3.0), C15:0(6.0)

 

8a

57.5

59.7

C15:0(6.1), C16:1(2.0), C16 index(2.5)

PIGO, STOML2

8b

79.9

98.4

C14:0(3.9), C18:0(4.1), CLA(3.3)

 

9a

25.5

25.6

C14:1(1.7)

 

9b

81.3

81.3

C15:0(5.0)

 

10a

1.1

8.6

C10:0(2.0), C12:0(3.5)

 

10b

12.9

12.9

C14:1(1.6), C18:0(3.6)

SLC51B

10c

78.1

80.1

C18:3n3(4.9)

PIGH

10d

87.5

93.1

C18:0(4.1), CLA(3.4), C18 index(2.5)

 

11a

24.7

26.7

C16:0(2.6)

ABCG5, ABCG8

11b

58.81

58.89

C16:0(2.8)

 

12a

17.1

17.1

C18:1c9(3.5)

 

12b

24.0

24.8

C14:1(1.8)

ALG5

12c

70.0

77.4

CLA(3.5), C16 index(2.5)

 

13

64.6

65.7

C10:0(2.4)

ACSS2

14a

1.5

5

C8:0(7.8), C10:0(3.6), C14:0(8.8), C14:1(2.1), C15:0(16.3), C16:0(33.8), C16:1(7.8), C18:1c9(34.1), C18:2n6(34.3), C18:3n3(24.2), CLA(14.6), C14 index(4.5), C16 index(11.3), C18 index(11.4)

DGAT1, GPAA1

14b

5.2

20

C8:0(4.3), C10:0(2.7), C15:0(5.2), C16:0(11.2), C16:1(6.6), C18:1c9(10.5), C18:2n6(15.2), C18:3n3(12.8), CLA(4.7), C14 index(1.8), C16 index(3.4), C18 index(4.4)

ST3GAL1

14c

44.7

49.9

C14:1(2.0), C16:1(1.9), C14 index(1.6), C18 index(2.7)

PMP2, FABP9, FABP4

FABP12

15a

27.2

31.2

C10:0(2.3), C14:0(4.6), C18:0(4.6)

APOA1, APOA4, APOA5, DPAGT1

15b

46.9

65.9

C10:0(2.8)

CAT

16a

23.8

25.22

C18:0(3.8), C16 index(2.3)

 

16b

57.53

57.58

C16:1(1.7), C16 index(2.1)

 

17a

17.4

22.6

C16:1(3.0), C16 index(2.1)

MGST2

17b

27.8

44.1

C8:0(5.9), C10:0(3.0), C16:1(2.6), C18:3n3(4.8), C16 index(2.3)

LARP1B

19

37.3

61.3

C8:0(7.6), C10:0(12.6), C12:0(13.6), C14:0(22.3), C16:0(4.6), C18:1c9(3.9), C14 index(3.1), C18 index(2.5)

ACLY, BRCA1, FASN, STAT5A,

20a

32.4

34.2

C16:1(1.9), C18:0(4.3)

PRKAA1

20b

36.7

36.9

C14:1(1.6), C18:1c9(3.9)

 

20c

55.3

60.4

C14 index(1.6), C18 index(2.8)

 

21

53.8

59.1

C10:0(2.3), C12:0(2.9), C14:0(3.3), C18:1c9(4.1)

 

22

59.12

59.13

C14 index(1.6)

 

23a

26.7

32.7

CLA(4.3)

AGPAT1, ATAT1

23b

33.5

36.5

C15:0(5.8)

 

23c

40.7

43.5

C18:1c9(3.4), C16 index(2.1), C18 index(2.6)

 

24

10.2

10.2

C18:0(4.2)

 

25a

9.8

9.9

C12:0(3.1)

 

25b

24.7

24.7

C18:1c9(3.5)

 

25c

41.4

41.7

CLA(3.0) C14 index(1.4)

 

26

2.9

43.0

C8:0(3.7), C10:0(5.5), C12:0(3.3), C14:0(8.0), C14:1(39.0), C16:0(2.4), C16:1(13.6), C18:0(4.5), C14 index(45.3), C16 index(19.7), C18 index(3.3)

SCD, ELOVL3, ACSL5, GPAM

27

37.0

42.2

C16:0(2.9)

 

28

36.6

37.2

C16:1(2.3), C16 index(2.5)

 

29

32.9

40.5

C16:0(2.5), C18:1c9(3.2)

TKFC

  1. aBTA number with subscript of alphabets to denote the multiple regions within a chromosome
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