Fig. 1

Dendrogram showing replicates cluster by mother and not by treatment in global CpG similarity. Mother is indicated by number, blue H: normal food and red L: calorie restricted replicate. Node support values in green were assessed by 10,000 bootstraps in pvclust, bootstrap probability and approximately unbiased methods had identical values. Dendrogram created using ward.D2 method in methylKit and pvclust. Number refers to mother from which that replicate was derived; H for normal food diet, L for caloric restriction