Fig. 4

Heatmap showing relative gene abundance of reactions associated with gene annotations of vitamin biosynthetic pathways in genome-scale metabolic models (GEMs) based on species abundance of abundant gut bacteria (a) American cohort and (b) Chinese cohort. The x-axis represents the reaction IDs associated to each vitamin pathway and on the y-axis the list of abundant gut bacteria are shown. Light blue and dark blue (on the left) represents healthy and diseased of associated reaction abundance to each microbial species (on the right) respectively. Grey color in every row represents absence of species in the cohort and the purple color key (dark to light color) represents abundance from high to low values