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Fig. 1 | BMC Genomics

Fig. 1

From: Genetic background modifies phenotypic and transcriptional responses in a C. elegans model of α-synuclein toxicity

Fig. 1

Gene expression varies with genetic background in C. elegans ILs constitutively expressing α-synuclein. a Principal component analysis on gene expression differences, with genotypes represented by shape and α-synuclein (aS) expressing ILs indicated with a black point. Estimated age difference is shown by the colour gradient. Here, developmental age was determined based on the expression levels of class I age responsive genes from Snoek et al. [41], which show a linear increase in expression during development between 46 and 54 h. This indicated a maximum developmental difference of a 2.5 h between genotypes. b Venn diagram of differentially expressed genes that are specific to aS, Genotype, Age and aS x Genotype including both induced and repressed genes

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