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Table 1 The top-20 enriched GO-terms with 5 or more genes with an α-synuclein effect

From: Genetic background modifies phenotypic and transcriptional responses in a C. elegans model of α-synuclein toxicity

GO_ID Description All Genes α-synuclein Genes Type p-value adjusted p
GO:0005576 extracellular region 329 54 CC 3.99E-06 8.29E-04
GO:0030246 carbohydrate binding 288 48 MF 8.12E-06 1.13E-03
GO:0005861 troponin complex 8 5 CC 1.21E-05 1.26E-03
GO:0055120 striated muscle dense body 93 21 CC 1.77E-05 1.48E-03
GO:0045087 innate immune response 300 47 BP 5.16E-05 3.06E-03
GO:0010332 response to gamma radiation 10 5 BP 7.77E-05 3.59E-03
GO:0006869 lipid transport 26 8 BP 2.74E-04 1.12E-02
GO:0098869 cellular oxidant detoxification 52 12 BP 5.12E-04 1.29E-02
GO:0030017 sarcomere 22 7 CC 4.10E-04 1.29E-02
GO:0006936 muscle contraction 17 6 BP 3.93E-04 1.29E-02
GO:0016810 hydrolase activity acting on carbon-nitrogen (but not peptide) bonds 13 5 MF 5.02E-04 1.29E-02
GO:0071949 FAD binding 18 6 MF 5.94E-04 1.37E-02
GO:0008652 cellular amino acid biosynthetic process 20 6 BP 1.23E-03 2.57E-02
GO:0043050 pharyngeal pumping 16 5 BP 1.85E-03 2.96E-02
GO:0016787 hydrolase activity 818 96 MF 2.24E-03 3.45E-02
GO:0016311 dephosphorylation 63 12 BP 3.36E-03 3.49E-02
GO:0030170 pyridoxal phosphate binding 48 10 MF 2.88E-03 3.49E-02
GO:0031430 M band 28 7 CC 2.46E-03 3.49E-02
GO:0003993 acid phosphatase activity 28 7 MF 2.46E-03 3.49E-02
GO:0099132 ATP hydrolysis coupled cation transmembrane transport 23 6 BP 3.08E-03 3.49E-02
  1. CC cellular component, MF molecular function, BP biological process