Genetic background modifies phenotypic and transcriptional responses in a C. elegans model of α-synuclein toxicity

Table 1 The top-20 enriched GO-terms with 5 or more genes with an α-synuclein effect

GO_ID	Description	All Genes	α-synuclein Genes	Type	p-value	adjusted p
GO:0005576	extracellular region	329	54	CC	3.99E-06	8.29E-04
GO:0030246	carbohydrate binding	288	48	MF	8.12E-06	1.13E-03
GO:0005861	troponin complex	8	5	CC	1.21E-05	1.26E-03
GO:0055120	striated muscle dense body	93	21	CC	1.77E-05	1.48E-03
GO:0045087	innate immune response	300	47	BP	5.16E-05	3.06E-03
GO:0010332	response to gamma radiation	10	5	BP	7.77E-05	3.59E-03
GO:0006869	lipid transport	26	8	BP	2.74E-04	1.12E-02
GO:0098869	cellular oxidant detoxification	52	12	BP	5.12E-04	1.29E-02
GO:0030017	sarcomere	22	7	CC	4.10E-04	1.29E-02
GO:0006936	muscle contraction	17	6	BP	3.93E-04	1.29E-02
GO:0016810	hydrolase activity acting on carbon-nitrogen (but not peptide) bonds	13	5	MF	5.02E-04	1.29E-02
GO:0071949	FAD binding	18	6	MF	5.94E-04	1.37E-02
GO:0008652	cellular amino acid biosynthetic process	20	6	BP	1.23E-03	2.57E-02
GO:0043050	pharyngeal pumping	16	5	BP	1.85E-03	2.96E-02
GO:0016787	hydrolase activity	818	96	MF	2.24E-03	3.45E-02
GO:0016311	dephosphorylation	63	12	BP	3.36E-03	3.49E-02
GO:0030170	pyridoxal phosphate binding	48	10	MF	2.88E-03	3.49E-02
GO:0031430	M band	28	7	CC	2.46E-03	3.49E-02
GO:0003993	acid phosphatase activity	28	7	MF	2.46E-03	3.49E-02
GO:0099132	ATP hydrolysis coupled cation transmembrane transport	23	6	BP	3.08E-03	3.49E-02