Table 1 The top-20 enriched GO-terms with 5 or more genes with an α-synuclein effect
GO_ID | Description | All Genes | α-synuclein Genes | Type | p-value | adjusted p |
|---|---|---|---|---|---|---|
GO:0005576 | extracellular region | 329 | 54 | CC | 3.99E-06 | 8.29E-04 |
GO:0030246 | carbohydrate binding | 288 | 48 | MF | 8.12E-06 | 1.13E-03 |
GO:0005861 | troponin complex | 8 | 5 | CC | 1.21E-05 | 1.26E-03 |
GO:0055120 | striated muscle dense body | 93 | 21 | CC | 1.77E-05 | 1.48E-03 |
GO:0045087 | innate immune response | 300 | 47 | BP | 5.16E-05 | 3.06E-03 |
GO:0010332 | response to gamma radiation | 10 | 5 | BP | 7.77E-05 | 3.59E-03 |
GO:0006869 | lipid transport | 26 | 8 | BP | 2.74E-04 | 1.12E-02 |
GO:0098869 | cellular oxidant detoxification | 52 | 12 | BP | 5.12E-04 | 1.29E-02 |
GO:0030017 | sarcomere | 22 | 7 | CC | 4.10E-04 | 1.29E-02 |
GO:0006936 | muscle contraction | 17 | 6 | BP | 3.93E-04 | 1.29E-02 |
GO:0016810 | hydrolase activity acting on carbon-nitrogen (but not peptide) bonds | 13 | 5 | MF | 5.02E-04 | 1.29E-02 |
GO:0071949 | FAD binding | 18 | 6 | MF | 5.94E-04 | 1.37E-02 |
GO:0008652 | cellular amino acid biosynthetic process | 20 | 6 | BP | 1.23E-03 | 2.57E-02 |
GO:0043050 | pharyngeal pumping | 16 | 5 | BP | 1.85E-03 | 2.96E-02 |
GO:0016787 | hydrolase activity | 818 | 96 | MF | 2.24E-03 | 3.45E-02 |
GO:0016311 | dephosphorylation | 63 | 12 | BP | 3.36E-03 | 3.49E-02 |
GO:0030170 | pyridoxal phosphate binding | 48 | 10 | MF | 2.88E-03 | 3.49E-02 |
GO:0031430 | M band | 28 | 7 | CC | 2.46E-03 | 3.49E-02 |
GO:0003993 | acid phosphatase activity | 28 | 7 | MF | 2.46E-03 | 3.49E-02 |
GO:0099132 | ATP hydrolysis coupled cation transmembrane transport | 23 | 6 | BP | 3.08E-03 | 3.49E-02 |