The identification of differentially expressed genes between extremes of placental efficiency in maternal line gilts on day 95 of gestation

Krombeen, Shanice K.; Shankar, Vijay; Noorai, Rooksana E.; Saski, Christopher A.; Sharp, Julia L.; Wilson, Matthew E.; Wilmoth, Tiffany A.

doi:10.1186/s12864-019-5626-0

Table 2 Candidate genes in high PE compared to low PE placentas

From: The identification of differentially expressed genes between extremes of placental efficiency in maternal line gilts on day 95 of gestation

Gene Symbol	Gene Name	log₂FC^a	FDR P-value²	Gene Ontology (MF; BP)^b
SAA2	Serum Amyloid A2	4.89	0.00002	binding, molecular transducer activity; locomotion
SPHKAP	Sphingosine Kinase Type 1	2.88	0.00388	binding
DKK1	Dickkopf-1	2.80	0.00876	binding, molecular transducer activity, molecular function regulator; biological regulation
CYP4F22	Cytochrome P450 Family 4 Subfamily F Member 22	2.44	0.05077	catalytic activity; metabolic process
FBP2	Fructose-1, 6-Bisphosphatase Isoenzyme 2	2.42	0.08290	catalytic activity; metabolic process
PCDHB1	Protocadherin Beta-1 Isoform X2	2.42	0.00302	;biological adhesion
SLC45A3	Solute Carrier Family 45 Member 3	1.89	0.07267	transporter activity, metabolic process
ASIC1	Acid Sensing Ion Channel 1 Isoform X2	1.81	0.05118	transporter activity; biological regulation, localization, multicellular organismal process
CELA1	Chymotrypsin-like Elastase Family Member 1	1.55	0.04841	catalytic activity
LEP	Leptin	1.01	0.05194	growth factor activity, hormone activity^c
ATP13A3	Probable Cation-Transporting ATPase 13A3	0.82	0.06425	; biological regulation
SLC4A7	Solute Carrier Family 4 Member 7	0.77	0.04207	transporter activity
CTSH	Pro-cathepsin H	0.71	0.07854	; positive regulation of angiogenesis^c
SLC52A3	Solute Carrier Family 52 Member 3	0.68	0.01438	molecular transducer activity; biological regulation
SLC23A2	Solute Carrier Family 23 Member 2	0.59	0.06802	transporter activity; localization
AGR2	Anterior Gradient Protein 2 Homolog	−2.99	0.00045	; biological regulation, cellular process
EMB	Embigin	−2.06	0.01288	binding; biological adhesion, cellular process
STEAP1	Six-Transmembrane Epithelial Antigen of Prostate 1	−1.98	0.05194	catalytic activity; localization
SARDH	Sarcosine Dehydrogenase	−1.89	0.02504	catalytic activity; metabolic process
STEAP2	Six Transmembrane Epithelial Antigen of the Prostate 2	−1.72	0.07267	catalytic activity; localization
MRP4	Multidrug Resistance-Associated Protein 4-like	−1.61	0.07267	transporter activity
KCNJ2	Potassium Channel, Inwardly Rectifying Subfamily J, Member 2	−1.31	0.00875	transporter activity
ANGPT1	Angiopoietin-1	−0.75	0.07031	binding; biological regulation, biological adhesion

^alog₂FC log₂ fold change. ²FDR P-value False discovery rate adjusted P-value, level of significance P < 0.10. ^bMF Molecular function, BP biological process. Genes above dotted line were among ten most upregulated or downregulated. ^cNo hits for Panther GO slim terms, specific GO terms used instead

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ISSN: 1471-2164

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