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Table 3 Predicted upstream regulators from IPA analysis

From: A cmap-enabled gene expression signature-matching approach identifies small-molecule inducers of accelerated cell senescence

Upstream regulator Gene description
In IR and p21
 ESR1 Estrogen receptor
 FOXM1 Forkhead Box M1
 NUPR1 Nuclear protein, transcriptional regulator 1
 KDM5B Chromobox Homolog 5
 CDKN1A Cyclin Dependent Kinase Inhibitor 1A
In IR only
 CBX5 Chromobox Homolog 5
 AURKB Aurora Kinase B
 KIAA1524 KIAA1524
 ANXA2 Annexin A2
 MAPK1 Mitogen-Activated Protein Kinase 1
 H2AFY H2A Histone Family Member Y
 EPAS1 Endothelial PAS Domain Protein 1
 CCL5 C-C Motif Chemokine Ligand 5
 ERBB2 Erb-B2 Receptor Tyrosine Kinase 2
 TGFBR2 Transforming Growth Factor Beta Receptor 2
 AR Androgen Recptor
In p21 only
 COL18A1 Collagen Type XVIII Alpha 1 Chain
 EZH2 Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit
 KLF4 Kruppel Like Factor 4