Table 3 Predicted upstream regulators from IPA analysis
Upstream regulator | Gene description |
|---|---|
In IR and p21 | |
 ESR1 | Estrogen receptor |
 FOXM1 | Forkhead Box M1 |
 NUPR1 | Nuclear protein, transcriptional regulator 1 |
 KDM5B | Chromobox Homolog 5 |
 CDKN1A | Cyclin Dependent Kinase Inhibitor 1A |
In IR only | |
 CBX5 | Chromobox Homolog 5 |
 AURKB | Aurora Kinase B |
 KIAA1524 | KIAA1524 |
 ANXA2 | Annexin A2 |
 MAPK1 | Mitogen-Activated Protein Kinase 1 |
 H2AFY | H2A Histone Family Member Y |
 EPAS1 | Endothelial PAS Domain Protein 1 |
 CCL5 | C-C Motif Chemokine Ligand 5 |
 ERBB2 | Erb-B2 Receptor Tyrosine Kinase 2 |
 TGFBR2 | Transforming Growth Factor Beta Receptor 2 |
 AR | Androgen Recptor |
In p21 only | |
 COL18A1 | Collagen Type XVIII Alpha 1 Chain |
 EZH2 | Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit |
 KLF4 | Kruppel Like Factor 4 |