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Table 4 Top 20 hits identified through the Connectivity Map

From: A cmap-enabled gene expression signature-matching approach identifies small-molecule inducers of accelerated cell senescence

Rank Name Mean n Enrichment P-value Specificity
1 Etoposide 0.859 2 0.999 0 0
2 Pyrvinium 0.832 4 0.994 0 0
3 Vorinostat 0.595 7 0.952 0 0.1101
6 15-delta prostaglandin 0.635 8 0.828 0 0.0299
7 Trichostatin A 0.519 92 0.776 0 0.1137
8 Thioridazine 0.507 11 0.703 0 0.0233
9 Sirolimus 0.288 25 0.631 0 0.0241
11 Puromycin 0.724 2 0.996 0.00002 0.0215
12 Phenoxybenzamine 0.709 3 0.992 0.00002 0.0394
13 Trifluoperazine 0.514 9 0.724 0.00002 0.0337
15 Rottlerin 0.632 3 0.972 0.00004 0.0052
16 Fulvestrant 0.332 21 0.529 0.00004 0.0971
17 Ionomycin 0.663 3 0.96 0.0001 0.0053
18 Withaferin A 0.711 2 0.986 0.00034 0.0212
19 Daunorubicin 0.605 3 0.938 0.0004 0.034
20 Clotrimazole 0.606 3 0.937 0.0004 0.0161
22 Hycanthone 0.658 2 0.985 0.00044 0.0209
24 Niclosamide 0.68 2 0.984 0.00048 0.0101
26 Nortriptyline 0.673 2 0.983 0.00056 0
28 Ivermectin 0.659 2 0.98 0.0007 0.0152
  1. Hits are limited to perturbagens examined with MCF7 and that yielded a positive score. Under the name of the perturbagen, all instances (different concentration or batch of the same perturbagen for treatment) are included and the mean is the arithmetic mean of the connectivity scores for those instances. The list is ranked based on ascending order of p-value then ascending order of enrichment