A cmap-enabled gene expression signature-matching approach identifies small-molecule inducers of accelerated cell senescence

Table 4 Top 20 hits identified through the Connectivity Map

Rank	Name	Mean	n	Enrichment	P-value	Specificity
1	Etoposide	0.859	2	0.999	0	0
2	Pyrvinium	0.832	4	0.994	0	0
3	Vorinostat	0.595	7	0.952	0	0.1101
6	15-delta prostaglandin	0.635	8	0.828	0	0.0299
7	Trichostatin A	0.519	92	0.776	0	0.1137
8	Thioridazine	0.507	11	0.703	0	0.0233
9	Sirolimus	0.288	25	0.631	0	0.0241
11	Puromycin	0.724	2	0.996	0.00002	0.0215
12	Phenoxybenzamine	0.709	3	0.992	0.00002	0.0394
13	Trifluoperazine	0.514	9	0.724	0.00002	0.0337
15	Rottlerin	0.632	3	0.972	0.00004	0.0052
16	Fulvestrant	0.332	21	0.529	0.00004	0.0971
17	Ionomycin	0.663	3	0.96	0.0001	0.0053
18	Withaferin A	0.711	2	0.986	0.00034	0.0212
19	Daunorubicin	0.605	3	0.938	0.0004	0.034
20	Clotrimazole	0.606	3	0.937	0.0004	0.0161
22	Hycanthone	0.658	2	0.985	0.00044	0.0209
24	Niclosamide	0.68	2	0.984	0.00048	0.0101
26	Nortriptyline	0.673	2	0.983	0.00056	0
28	Ivermectin	0.659	2	0.98	0.0007	0.0152

Hits are limited to perturbagens examined with MCF7 and that yielded a positive score. Under the name of the perturbagen, all instances (different concentration or batch of the same perturbagen for treatment) are included and the mean is the arithmetic mean of the connectivity scores for those instances. The list is ranked based on ascending order of p-value then ascending order of enrichment

ISSN: 1471-2164