Fig. 3

Top 15 affected pathways as indicated by IPA. Within the top affected pathways “cAMP-mediated signalling” or “Axonal Guidance Signalling” could be detected. The z-score indicates a prediction of activation or inhibition of a specific pathway based on experimentally determined gene expression data and the IPA ‘knowledge base’. A positive z-score (activation) was only predicted for IL-6 Signaling. But for most of the pathways no prediction regarding activation or inactivation could be made