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Table 3 Candidate genes related to pathways potentially associated with endoparasite resistance

From: Genome-wide associations and functional gene analyses for endoparasite resistance in an endangered population of native German Black Pied cattle

Pathway

Endoparasite trait

Candidate gene (BTA)a

Possible association to endoparasite infections

Cell adhesion molecules pathway

rFEC-FH

ALCAM (BTA1),

Cell adhesion interactions of T cellsb

 

rFLC-DV

CDH2 (BTA 24)

 

Cytokine-cytokine interaction pathway

rFEC-GIN

EGFR (BTA 22)

Intercellular regulation and mobilization of adaptive immune response cellsb

Estrogen signaling pathway

rFEC-GIN

EGFR (BTA 22)

Increase in reproduction rate of parasites as a result of increasing metabolism of 17-ß-estradiol in its host [74,75,76]

PI3K-Akt signaling pathway

rFEC-GIN

EGFR (BTA 22), PHLPP1 (BTA 24)

Important functions in cellular immune responseb

  1. aGene ID (chromosomal location); bBased on annotation in KEGG pathway [60]; BTA Bos taurus chromosome, rFEC-GIN Residuals of fecal egg counts for gastrointestinal nematodes, rFEC-FH Residuals of fecal egg counts for Fasciola hepatica, rFLC-DV Residuals of fecal larvae counts for Dictyocaulus viviparus