Pathway | Endoparasite trait | Candidate gene (BTA)a | Possible association to endoparasite infections |
---|---|---|---|
Cell adhesion molecules pathway | rFEC-FH | ALCAM (BTA1), | Cell adhesion interactions of T cellsb |
 | rFLC-DV | CDH2 (BTA 24) |  |
Cytokine-cytokine interaction pathway | rFEC-GIN | EGFR (BTA 22) | Intercellular regulation and mobilization of adaptive immune response cellsb |
Estrogen signaling pathway | rFEC-GIN | EGFR (BTA 22) | Increase in reproduction rate of parasites as a result of increasing metabolism of 17-ß-estradiol in its host [74,75,76] |
PI3K-Akt signaling pathway | rFEC-GIN | EGFR (BTA 22), PHLPP1 (BTA 24) | Important functions in cellular immune responseb |