Comprehensive kinome NGS targeted expression profiling by KING-REX

BMC Genomics

Table 3 Prediction of kinase fusion events

Sample	Kinase	FC	P-value	IN_A	IN_B	OUT_A	OUT_B
KARPAS 299	ALK	15.83	2.00E-308	12.8	12.9	0.0	0.0
KM-12	NTRK1	10.58	3.94E-236	12.4	12.1	2.3	1.6
LC-2/ad	RET	10.79	6.23E-219	11.8	11.7	1.6	1.6
U-118 MG	ROS1	13.85	4.58E-174	10.9	10.7	0.0	0.0
NCI-H716	FGFR2	–	–

Imbalanced kinases detected by KING-REX analysis in a panel of cancer cell lines harboring known kinase gene fusions. (FC = Log2 fold change between ASSAY IN and ASSAY OUT; IN = ASSAY IN expression value for duplicates A and B; OUT = ASSAY OUT expression value for duplicates A and B). For differential expression below EdgeR p-value default threshold, no data are reported in the table

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