Fig. 3

Heatmaps of pangenome categories. a Distribution of genes amongst 226 O. oeni strains annotated for “resistance” or “toxin”, b amino acid biosynthesis pathways or c Phosphotransferase systems. Orientation of the heatmaps is transposed from Fig. 2, listing strains on the columns and MICFAMs on the rows. The order of the strains is the same as in the pangenome, while the MICFAMs were clustered anew (complete linkage). Phylogenetic groups A-D and strain names are indicated on the top and bottom, respectively. In a, light blue color indicates the presence of a gene fragment. In b, pathway completion is colored according to KEGG metabolic pathway maps. (Note that some pathways overlap). In c, light to dark colors indicate the number of components present for a given PTS (between 1 and 4), listed by substrate and gene/transporter name