Fig. 2

MiCoP and MetaPhlAn2 HMP Virus Profiling Results. Abundance estimation for viruses when applying MiCoP and MetaPhlAn2 to 20 Human Microbiome Project samples, 10 from buccal mucosa and 10 from tongue dorsum. MiCoP detects a total of 34 species present, with the sample being dominated by bacterial phages, particularly Streptococcus phages. MetaPhlAn finds a much lower virome diversity than MiCoP, with only 12 species identified. The sample is again dominated by Streptococcus phages, but MetaPhlAn’s results suggest that there is only a single type of this phage dominating the sample, while MiCoP suggests that a wide variety of Streptococcus phages are present. MetaPhlAn’s results may stem from the reference bias issue explored in the simulation studies