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Fig. 1 | BMC Genomics

Fig. 1

From: G-quadruplexes may determine the landscape of recombination in HSV-1

Fig. 1

Genome-wide distribution of recombination breakpoints mirrors G4 densities in HSV-1. A nucleotide window of 100 bp was slid across the genome of HSV-1 strain 17 (Genbank accession number: NC_001806) at a step size of 1 bp (i.e a total of 152162 windows were analyzed for a genome that is 152,163 bp long). The G4 density and the number of breakpoints in each window were computed; the fold difference over their respective genomic averages was calculated window-wise and smoothened line graphs are plotted. The green line at 1 represents the normalized genome-wide average and demarcates the regions of local enrichment (above the green line) and depletion (below the green line). The blue and red lines superimpose each other genome-wide, indicating a spatial association between recombination breakpoints and G4-motifs in the HSV-1 genome

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