Fig. 4

Gene-set network analysis of early-onset colorectal cancer data. a Gene-set networks/clusters obtained using pMM (GSEA FDR < 0.01). Pink and green nodes represent up- or down-regulation of gene-sets, respectively. Overlapping clusters were represented by dashed circles. The cluster labels were manually written by the authors. The sizes of node and gene-set name are adjustable on the web. b Gene-set clusters of fatty acid metabolism derived from pMM, MM, and KAPPA, respectively. In the pMM cluster, nodes bordered by orange and blue boxes indicate gene-sets that were not included in the MM and KAPPA cluster, respectively. c PPI network (score ≥ 0.5) of significant genes (FDR < 0.01) in cellular respiration cluster. SDHB was the hub (degree = 25). d PPI networks connected with SDHB in cellular respiration cluster. Met represents Metabolism