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Table 2 Identified virulence factors and antigen proteins in MTB

From: Investigating function roles of hypothetical proteins encoded by the Mycobacterium tuberculosis H37Rv genome

ORF

Accession number

Annotated gene

Our annotation

Antigen protein

Rv2707

NP_217223.1

rpoS

RNA polymerase sigma factor rpoS

NO

Rv0674

NP_215188.1

pspA

Phage shock protein pspA

YES

Rv1518

NP_216034.1

wcaA

Colanic acid biosynthesis glycosyl transferase wcaA

YES

Rv0498

NP_215012.1

tagE

alpha-glucosyltransferase

YES

Rv1893

NP_216409.1

prm1

Plasma membrane fusion protein prm1

YES

Rv0546c

NP_215060.1

gloA

Lactoylglutathione lyase

YES

Rv1505c

NP_216021.1

epsM

acetyltransferase epsM

YES

Rv0049

NP_214563.1

ygaZ

Inner membrane protein ygaZ

YES

Rv2694c

NP_217210.1

artP

Arginine transport ATP-binding protein artP

NO

Rv2365c

NP_216881.1

ydbL

Protein ydbL

YES

Rv2327

NP_216843.1

slyA

Transcriptional regulator slyA

YES

Rv2751

NP_217267.1

yktD

adenosyl-methionine-dependent methyltransferase yktD

YES

  1. Twelve new virulence factors were found in MTB in this study. The antigen proteins could be applied to vaccine development for the prevention of MTB