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Table 3 Potential drug targets of MTB HPs

From: Investigating function roles of hypothetical proteins encoded by the Mycobacterium tuberculosis H37Rv genome

ORF

protein ID

ChEMBL ID

Drug name

Mechanism of Action

Rv0817c

NP_215332.1

CHEMBL2095222

ocriplasmin

Laminin hydrolytic enzyme inhibitor

Rv2927c

NP_217443.1

CHEMBL2105700

bedaquiline fumarate

ATP synthase inhibitor

Rv1303

NP_215819.1

CHEMBL3989689

squalamine

Sodium/hydrogen exchanger 3 inhibitor

Rv2908c

NP_217424.1

CHEMBL564085

troleandomycin

70S ribosome inhibitor

Rv2926c

NP_217442.1

CHEMBL614

pyrazinamide

Fatty acid synthase inhibitor

Rv0312

NP_214826.1

CHEMBL1201780

carglumic acid

Carbamoyl-phosphate synthase inhibitor

  1. Six essential HPs were identified with potential drug targets