Fig. 2

Changes of protein levels as monitored by quantitative mass spectrometry throughout the growth phases. Levels of proteins in later growth phases were normalized to protein levels in the exponential phase. Box plots (a) give an overview on the proteome variability of the different samples. Kernel density estimators (KDE) (b) compare the distribution of growth phase-dependent changes in protein levels. The heat map (c) gives a global overview of the changes in protein levels for each individual gene. The ranking of genes is based upon the degree of log₂FC observed in transition phase, with the highest increases in protein abundance in the transition phase appearing at the top of the heat map. Indicated underneath the heat map is the total number of proteins detected at each growth phase