Fig. 2

Comparison of RNA-binding affinities of two proteins. The RNA-binding properties of two proteins have been compared in this case study, on the basis of predictions made by RStrucFam. a. Structural alignment of the two proteins. The RNA-binding residues in 2B3JD (on the basis of 5 Å distance cut-off criterion) have been highlighted in yellow, whereas the structurally aligned residues in 2G6VA have been highlighted in cyan. The same colour scheme have also been followed in panels B and C of this figure. b. Structure of the 2B3JD-2B3JH complex (left pane) and its electrostatics properties on the solvent accessible surface (right pane). c. Structure of the 2G6VA-2B3JH complex (left pane) and its electrostatics properties on the solvent accessible surface (right pane). d. The potential energies of the two complexes (in kcals/mol) have been tabulated. These values were calculated using SYBYL7.2 (Force Field: Tripos, Electrostatics: None) in vacuum, post energy minimisations until convergence