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Table 1 Summary of DNA methylation sites significantly rejecting the assumptions of linear regression

From: Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array

  Global Skewness Kurtosis Link Function Heteroskedasticity
N reject null hypothesis 577,919 332,457 544,460 59,572 35,001
% reject null hypothesis 71.8 41.3 67.6 7.4 4.3
  1. For each of the 5 tests performed by the gvlma package the number and percentage of DNA methylation sites with significant p-values (P < 9.42 × 10− 8) are reported