Fig. 2

The predicted biosynthetic gene cluster BIIRfg. a Gene organization of the predicted biosynthetic gene cluster. Red arrows show the biosynthetic genes while yellow ones are other genes present in the vicinity. The direction of arrows corresponds to that of the reading frame. The neighboring orfs of NRPS and PKS genes are labelled a, b, c, d, e, f, g, h, i, j and k. b Domain structure of the NRPS gene: The green ovals labelled An (n = 1..8) represent adenylation domains. The orange ovals labelled Cn (n = 1..8) represent condensation domains. The predicted condensation domain, which was not predicted by antiSMASH, is shown in yellow oval. The last condensation domain is labelled as CT and is shown in red oval. The pink ovals labelled En (n = 1,2) represent epimerization domains. Cyan ovals labelled PCPn (n = 1..9) represent peptidyl carrier protein (PCP) domains. The constituent modules in the cluster are marked from 1 to 10. c Domain structure of PKS gene: T1-PKS module consists of a beta-ketoacyl synthase (KS) domain shown in green, acyltransferase (AT) domain in orange, dehydratase (DH) domain in magenta, methyltransferase (cMT) domain in grey, enoyl reductase (ER) domain in cyan, ketoreductase (KR) in yellow and acyl carrier protein (ACP) domain in red